Animal Models

Leading the Way with Animal Models

At Creative Biolabs, we take pride in our extensive collection of animal models, with a particular emphasis on mouse models. These invaluable resources are instrumental in driving groundbreaking research and innovation across various fields.

Why Animal Models Matter

Our diverse range of animal models serves as the cornerstone of our research efforts, enabling us to explore complex biological phenomena, investigate disease mechanisms, and develop cutting-edge therapeutic interventions. Through meticulous genetic engineering and precise manipulation, we have cultivated a comprehensive repository of mouse models that faithfully recapitulate human diseases, making them indispensable assets in the pursuit of medical advancements.

In summary, gene editing in mouse models offers a versatile platform for research across various fields, including disease modeling, drug development, behavioral studies, immunology, and cancer biology, providing invaluable insights into life sciences.

Tab. Applications of mouse models.

Applications Description
Disease Modeling Gene editing in mouse models helps simulate human diseases, aiding in studying disease mechanisms, identifying therapeutic targets, and evaluating treatment effectiveness.
Functional Studies These models facilitate research into gene functions, shedding light on their roles in physiology and disease.
Drug Development and Testing Mouse models enable the testing of drug efficacy and safety, providing insights into drug responses and personalized treatments.
Gene Therapy Research Gene editing in mice is crucial for studying gene therapy approaches, including treating genetic diseases and assessing therapeutic targets.
Biological Research Mouse models contribute to understanding fundamental biological questions, such as gene regulation, cell signaling, and development processes.
Disease Progression Studies These models help in studying disease progression, aiding in the development of effective treatment strategies and preventive measures.
Drug Metabolism and Toxicity Testing Mouse models assist in studying drug metabolism and toxicity, improving drug safety and optimizing dosage regimens.
Behavioral and Cognitive Research Some mouse models are used to study behavior and cognition, advancing our understanding of neurological functions and cognitive diseases.
Immune System and Inflammation Research Gene editing in mouse models contributes to studying immune system functions, inflammation responses, and related diseases.
Tumor Biology and Cancer Treatment Mouse models are essential for studying tumor biology, evaluating cancer drug efficacy, and developing novel treatment strategies.

Creative Biolabs offers a diverse array of mouse models, complemented by our state-of-the-art Mouse Model Construction Platform, dedicated to the development of an even wider range of Mouse Models. Whether it's gene-editing-based techniques like gene knock-in, silencing, overexpression, mutation, or other custom requirements, we ensure the delivery of high-quality and highly reliable Mouse Models.

Our gene knock-in mouse models are meticulously engineered to accurately mimic genetic alterations found in human diseases, providing researchers with invaluable tools to study disease mechanisms and evaluate potential therapeutic interventions with precision and reliability.

Our gene-silencing mouse models utilize advanced gene editing techniques to silence specific genes, enabling researchers to unravel the intricate roles of genes in physiological processes and disease pathology. With our models, researchers can confidently explore new avenues for therapeutic development.

With our gene overexpressing mouse models, researchers gain access to models that faithfully replicate gene overexpression seen in various diseases. These models offer a robust platform for investigating gene function and screening potential therapeutics with a high degree of fidelity and reproducibility.

Our gene humanizing mouse models are engineered to express human genes in a mouse background, offering researchers an exceptional tool to study human-specific gene functions and disease mechanisms in an in vivo setting. Our models provide unparalleled accuracy and reliability for translational research.

Leveraging cutting-edge gene editing technologies, our gene mutation mouse models accurately recapitulate specific gene mutations associated with human diseases. Researchers can rely on our models to delve deep into the underlying molecular mechanisms of diseases and accelerate the development of targeted therapies with confidence and precision.

Additionally, we distinguish ourselves by providing Syngeneic Models and Humanized Models. Syngeneic Models, derived from mouse cells, are instrumental in studies such as immunotherapy, while Humanized Models involve the introduction of human cells or genes into mouse models, offering a closer representation of human physiology for disease research and drug development. With our comprehensive model selection, you'll be equipped to pursue a diverse range of research projects and achieve deeper scientific insights and meaningful experimental results."

With an unwavering commitment to scientific excellence and ethical research practices, we uphold the highest standards in animal care and welfare. Our state-of-the-art facilities provide optimal environments for our animal models, ensuring their well-being and enabling robust, reliable results. We leverage our collective expertise and resources to accelerate the pace of discovery and translate scientific findings into tangible solutions that improve human health and well-being.

Explore our vast portfolio of animal models and discover how Creative Biolabs is revolutionizing research and driving innovation in the life sciences. Don't hesitate to reach out to us to learn more about how our animal models can propel your research forward.

For Research Use Only | Not For Clinical Use

Filters

Product Type Immune Animal Model
Strain Name NSG (NOD, SCID, IL2Rg null)
Description This model can achieve the depletion of mouse T\B\NK cells by silencing NOD, SCID, and IL2Rg.
Product Type Immune Animal Model
Strain Name NSG (Db/Kd null)
Description This model achieves the goal of MHC-I knockout and GvHD reduction in hu-PBL mice (mice treated with PBMCs) by silencing H2-Db/H2-Kd.
Product Type Immune Animal Model
Strain Name NSG (MHC null)
Description This mouse model enables MHC-I/II knockout and GvHD delay in hu-PBL mice (mice treated with PBMCs) by silencing H2-DB/H2-Kd/H2-Ab1.
Product Type Immune Animal Model
Strain Name NSG (M-Kit W41)
Description This mouse model enables irradiation-free hematopoietic stem cell engraftment and improved human erythropoiesis and platelet formation through Kit W41 mutation.
Product Type Immune Animal Model
Strain Name NSG (FIk2/FLT3 null)
Description This model implements the function of impair the murine DC development by silencing FIk2/FLT3.
Product Type Immune Animal Model
Strain Name NSG (E-Tslp-K14)
Description In this model, Tslp is expressed through K14 pramoter, thereby achieving lymph node development in mice.
Product Type Immune Animal Model
Strain Name NSG (E-mIL2rg)
Description This model is based on the expression of mIL2rg in Lti cells to achieve lymph node development in mice.
Product Type Immune Animal Model
Strain Name NSG (FcgRs null)
Description This model achieves knockout mouse Fc-mediated function by silencing FcgRs (FcgR I/II/III/IV).
Product Type Immune Animal Model
Strain Name NSG (HLA A2 KI)
Description This model implements human CD8 T cell education by knocking in HLA A2.
Product Type Immune Animal Model
Strain Name NSG (HLA DR1 KI)
Description This model implements human CD4 T cell education by knocking in HLA DR1.
Product Type Immune Animal Model
Strain Name NSG (HLA E KI)
Description This model implements human NK education and HLA-E-restricted CD8+ T cell responses by knocking in HLA E.
Product Type Immune Animal Model
Strain Name NSG (E-hTHPO)
Description This mouse model enables irradiation-free hematopoietic stem cell engraftment and improved human erythropoiesis and platelet formation through over-expression of hTHPO.
Product Type Immune Animal Model
Strain Name NSG (hFLT3L)
Description This model enables human DC development in NSG (FIk2/FLT3 null) mice by humanizing FLT3L.
Product Type Immune Animal Model
Strain Name NSG (E-hIL2)
Description This model helps to study adoptive cellular immunity in solid tumors by overexpressing hIL2.
Product Type Immune Animal Model
Strain Name NSG (E-hIL3/hCSF2)
Description This model improves human myeloid cell development in hu-HSC (CD34⁺ HSCs treatment mice) mice by overexpressing hIL3/hCSF2.
Product Type Immune Animal Model
Strain Name NSG (hIL7)
Description This model improves thymopoiesis in thymus and human B cell development by humanizing the IL7 gene.
Product Type Immune Animal Model
Strain Name NSG (hIL15)
Description This model improves numbers of memory CD8T cells and human NK development/proliferation by humanizing the IL15 gene.
Product Type Immune Animal Model
Strain Name NSG (hCD47)
Description This model aims to reduce anemia in in myeloid-enhanced mice and study the cytotoxicity of anti-CD47 antibodies by humanizing the CD47 gene.
Product Type Immune Animal Model
Strain Name NSG (hFcRN/hAlbumin)
Description This model is used to study the albumin-fusion protein ar albumin-binding protein by humanizing the FcRN and Albumin genes.
Product Type Immune Animal Model
Strain Name NSG (E-HSVtk)
Description This model achieves the effect of damaging the liver of mice to promote the engraftment of human hepatocytes by expressing HSVtk in liver cells.
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