Description
NF-kappaB luciferase reporter construct is stably integrated into the genome of A549 cells. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-kappaB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.
Applications
The NF-kappaB-luciferase / A549 cell line is suitable for monitoring the activity of NF-kappaB transcription factor through luminescence readout instead of using electrophoretic mobility shift assay (EMSA). It provides a platform to enable study of a plet
Common Name
NF-kappaB cell line, NFkappaB cell line, luciferase reporter, NF-kB cell line, NFkB cell line
Datasheet