Description
Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Human TIGIT Stable Cell Line, CHO-K1 is constructed to constitutively expressing Human TIGIT. Which can be used in binding assays and functional assay.
Features
Stable cell lines for increased reliability and reproducibility;
Protein expression at the cell surface validated by FACS or WB;
Applications
The cell line can be used in binding assay or function assay in vitro.
Organism
Human
Strain Name
CHO-K1
Common Name
TIGIT
Background
TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.

For Research Use Only | Not For Clinical Use

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