Woodchuck PD-1 & NFAT-Luciferase Reporter Recombinant Cell Line, Jurkat (CAT#: IOC-LX159)

Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of woodchuck (groundhog, Marmota monax) PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #HQ403652). Which can be used in binding assays and functional assay.

Stable cell lines for increased reliability and reproducibility;
Protein expression at the cell surface validated by FACS or WB;

• Screen for activators or inhibitors of woodchuck PD-1 signaling in a cellular context
• Characterize the biological activity of woodchuck PD-1 and its interactions with ligands

Woodchuck

Jurkat

PD-1 & NFAT-Luciferase Reporter

The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.