Tag Archives: ADC linker

22Dec/23

Key Points of ADC Optimization Strategy

December 22, 2023ReviewADC linker, ADC Optimization, antibody-drug conjugatebioadc

Antigen Target Selection A major challenge in developing antibody-drug conjugates (ADCs) for cancer lies in the identification and validation of sufficient antigen targets for the monoclonal antibody component. Several factors need toRead More…

14Sep/22

ADC Panoramic Overview-Linker

September 14, 2022ReviewADC linkerbioadc

The linker is not only the molecular part of the covalent connection between the antibody and the small molecular payload but also a key element with design properties in targeted drug therapy.Read More…

28Dec/21

New structures to resolve the instability of Maleimide joint

December 28, 2021Antibody-drug Conjugates ManufacturingADC, ADC linker, Hydrolyzed Maleimide linkerbioadc

An ADC consists of an antibody and toxin bridged by a linker that affects the coupling stability to some extent and has an important influence on ADC efficacy. The premature release ofRead More…