Targeting tumor cell apoptosis and angiogenesis Apoptosis (or programmed cell death) is an evolutionarily conservative process that maintains tissue homeostasis under cellular stress, DNA damage and immune surveillance. However, cancer cells canRead More…
The occurrence and development of cancer is a complex process, which is characterized by continuous proliferation signals, avoidance of growth inhibitors, resistance to cell death, induction of angiogenesis, activation of invasion andRead More…
Recently, Pfizer and Arvinas jointly announced that they have reached an agreement to co-develop and promote the PROTAC protein degrader ARV-471. Arvinas will receive $650 million in upfront payments and potentially upRead More…
Advantages of PROTAC technology Through PROTAC technology, it is possible to develop drugs against undruggable or difficult-to-drug targets of traditional inhibitors. The PROTAC does not rely on the active site ofRead More…
Over the past decade, major changes have taken place in the field of drug targets. Although traditional targets (such as kinases and G-protein-coupled receptors) are still the main stream, the focus isRead More…