Single chain IgGs (scIgGs) have same domains with IgGs, VH, CH1, CH2-CH3, VL and CL, but form a confined structure. The six units of a conventional IgG are expressed in the tandem fragments. The heavy chain and light chain of the same chain are fused via flexible linkers. And the two single chains from different parental antibodies dimerize through the KIH Fc, the resulted molecule has 1+1 antigen-binding valency for each antigen.
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