Indoleamine 2,3-dioxygenase (IDO) is an enzyme that plays a key role in tryptophan metabolism. It has three isoforms - IDO1, IDO2, and TDO. In cancer, the inflammation induced by tumor growth can lead to the overexpression of IDO in tumor cells and surrounding tissue. This may result in tryptophan depletion, hindering immune cell function and dampening the local immunological response in the tumor microenvironment. As a result, inhibiting IDO expression is being explored as a potential strategy for cancer immunotherapy.
Fig.1 Modulation of IDO1 overexpression and immune suppression in the tumor microenvironment.1
Incorporating medicinal chemistry, structural biology, and others, Creative Biolabs delivers a cost-effective indoleamine 2,3-dioxygenase (IDO) inhibitor development service for global customers to improve cancer immunotherapy. We provide a comparable complete targets library to help customers select the desirable targets for IDO inhibitor development. Several cutting-edge technologies such as high-throughput screening and smarter computer-aided design, enable our service compatible with different conditions. Based on it, we can develop variable inhibitor formats for customers' multiple uses.
Furthermore, we also provide tests to identify the candidate inhibitors to ensure their superior efficiency, selectivity, specificity, and other aspects. In addition, we have the capacity to construct research models for the toxicological assessment of candidate IDO inhibitors. Collectively, we provide a one-stop customized comprehensive service to assist global customers in developing effective IDO inhibitors and applying them to clinical trials.
Fig.2 Workflow.
Q1: What is the mechanism of action of IDO inhibitors?
A1: IDO is an enzyme that can hinder the immune system's ability to combat tumors by breaking down tryptophan, an essential amino acid for T cells. This degradation leads to the inhibition of T-cell function, allowing the tumor to evade detection. However, IDO inhibitors can block this process, restoring T cell activity and potentially enhancing the body's ability to fight against cancer cells.
For more details about our indoleamine 2,3-dioxygenase (IDO) inhibitor development service for cancer immunotherapy, please feel free to get in touch with us.
Reference
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