Abnormal levels of lipids are closely associated with carcinogenesis and cancer metastasis. Tumor lipid metabolic reprogramming allows them to survive and proliferate under conditions of nutrient deprivation and hypoxia. On the one hand, tumor cells can upregulate de novo lipogenesis to generate new lipids necessary for their growth and survival. On the other hand, tumor cells downregulate lipid catabolism to promote the accumulation of fatty acids in tumor cells, which can then be used for energy production or storage.
Fig.1 Lipid metabolic reprogramming in cancer.1
In order to better understand the lipid metabolic pathway, Creative Biolabs provides high-throughput technologies and bioinformatics services to analyze the lipid metabolic pathway. We utilize a series of advanced technologies such as lipidomics, metabolomics, genomics, and proteomics. We also perform a series of cellular metabolism assays to measure lipid uptake, metabolic pathway-related enzymes, and metabolites. By combining these different types of analysis, we can provide more comprehensive and accurate insights into the tumor lipid metabolic pathway.
We utilize lipidomics for quantitatively analyzing the composition and function of all lipids in cells or tissues at a given time, which can be used to screen potential biomarkers for cancer diagnosis and prognosis, as well as to study the changes of lipid species in different signaling pathways in tumors.
Fig.2 The workflow of lipidomics.2
We utilize genomics to study the genes related to lipid metabolism in tumors and their mutations, as well as to explore the regulation of lipid metabolism by transcription factors and miRNAs. Proteomics can be used to study the proteins and enzymes involved in lipid metabolism in tumors.
We have a professional team of scientists to provide you with one-stop services, including experimental design, sample collection, sample storage, data analysis, and data interpretation. We can also provide you with customization services according to your specific requirements so that you can better understand the role of the lipid metabolism pathway in cancer cells and abnormal lipid metabolism. If you have any requirements, please don't hesitate to contact us.
Method Used: Lipidomic
Journal: Genome medicine
Research Overview: This article utilized LC-MS and lipidomic profiles to analyze lipid metabolism in breast tumors. Based on the lipidomics findings and the silico transcription database, key enzymes of lipid biosynthesis were identified.
Fig.3 Analysis of lipid metabolism in breast tumors.3
References
For Research Use Only | Not For Clinical Use
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