On July 12, FDA experts will discuss whether CAR-T CTL019 can be on the market, which is an assessment of the CTL019 Biologics License Application (BLA) submitted by Novartis and will evaluate the dataRead More…
The Appearance of CAR-T
CAR-T (T cell chimeric antigen receptor), as an immune cell therapy has attracted worldwide attention including academics, doctors, patients, and investors. However, what’s CAR-T exactly? What’s the background of it? What’s the currentRead More…
The Exploration of CAR T Cells Validation
Chimeric antigen receptor (CAR) T cells have hit the cancer immunotherapy area in the past few years. ‘A CAR therapy for cancer, using a technique called adoptive cell transfer, has been approvedRead More…
The Development of CAR Gene Construction
CAR-T is chimeric antigen receptor T cell immunotherapy, which modifies T cell receptor by CAR and transforms it into the scFV segment in the binding domain of monoclonal antibodies. A classic CAR-TRead More…
The Introduction of T Cell Proliferation Assay
Cell proliferation is an important vital sign of the organism in a splitting manner. Single-celled organisms produce new individuals in the form of cell division, while a multicellular organism that produces newRead More…
TCR, A New Star of Immune Cell Therapy
Immune cell therapy, the fourth major cancer treatment following surgery, radiotherapy, and chemotherapy, has been recognized as the most active and promising treatment in the comprehensive tumor treatment in the 21st century.Read More…
Signal, Migration and Survival of CAR T Cells
CAR-T, Chimeric Antigen Receptor T-Cell Immunotherapy, is the most effective treatment of malignant tumors. Similar to other immunotherapy, its basic principle is to remove cancer cells in the use of the patient’s own immuneRead More…
CAR-T’s Era Is Really Coming!
On March 29, 2017, Novartis announced that the US FDA has issued a priority review for its CAR-T therapy CTL019 (tisagenlecleucel-T) biologics licensing application. The indications of CTL019 was recurrent or refractory B-cellRead More…