T-cell receptor-engineered T cells (TCR-T) represent a form of cellular immunotherapy and a subtype of adoptive cell transfer (ACT). It involves the identification and selection of TCR sequences capable of specifically bindingRead More…
Positive Outcomes in Clinical Trial of Cord Blood-Derived CAR-NK Cell Therapy for B Cell Malignancies
In a recent study, researchers from the University of Texas MD Anderson Cancer Center in the United States reported favorable results from a Phase I/II clinical trial involving 37 patients with relapsedRead More…
Enhancing CAR-T Cell Therapy: Modular Cytokine Receptors Boost Anti-Tumor Activity in Solid Tumors
The use of modified chimeric antigen receptor (CAR) T cells (CAR-T) in immunotherapy has significantly improved the survival rates of pediatric patients with relapsed leukemia. However, these therapies are not as effectiveRead More…
CAR-T Cell Therapy May Lead to HHV-6 Virus Reactivation
In a recent study, researchers from Stanford University in the United States collected data from previous studies on CAR-T cell therapy to investigate the reactivation of human herpesvirus 6 (HHV-6) in patientsRead More…
A Lego-Like Gene Editing Tool: ModPoKI, Paving the Way for Enhanced CAR-T Cell Therapy
In recent years, scientists have harnessed the power of gene editing technology to reprogram immune cells into therapies capable of targeting cancer. However, these immunotherapies are not universally effective across all patientsRead More…
Single Dose of CAR-T Cells Holds Promise for Effective Ovarian Cancer Treatment
In a recent study, researchers from the University of Illinois Urbana-Champaign in the United States have discovered that CAR-T cell immunotherapy could potentially be a highly effective treatment for solid tumors ifRead More…
The Loss of Metabolic Adaptability Reveals a Key Mechanism of Tumor Resistance in CAR-NK Cells
In a recent study conducted by researchers from institutions including the MD Anderson Cancer Center at the University of Texas, USA, it has been discovered that the loss of metabolic capacity inRead More…
A Revolutionary CAR-T Therapy with Potential for Blood Cancer Treatment
Immunotherapy strategies aim to utilize the patient’s own immune system cells to eliminate tumor cells. CAR-T cell therapy is an effective treatment for human blood cancers. In France, approximately 35,000 people areRead More…
An Improved Form of CAR-T Cell Therapy Shows Potential for Treating Myasthenia Gravis
A small-scale clinical trial suggests that an improved form of CAR-T cell therapy, known as Descartes-08, holds promise for treating myasthenia gravis, an autoimmune neuromuscular disease. The modified CAR-T therapy used inRead More…
HER2-targeting CAR-T Cells Show Promise for Show Promise for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive brain tumor that usually occurs in children between 5 and 7. This fast-growing tumor forms in the part of a child’s brain responsible forRead More…