The human leukocyte antigen (HLA) system or complex is a group of highly polymorphic genomes on chromosomes that encode major histocompatibility complex (MHC) proteins which are expressed on the surface of cellRead More…
PNAS: Targeting Tox and Tox2 is Expected to Improve the Treatment of Solid Tumors by CAR-T Cell Immunotherapy.
Ten years ago, scientists announced the development of cancer immunotherapy called chimeric antigen receptor-T cell (CAR-T) therapy: genetically modifying T cells from patients to make them powerful anti-tumor effects, and then infusingRead More…
For the first time! Production of CAR-T cells expressing anti-CD19 without virus and plasmid
Recently, it was announced that LineaRx (a part of Applied DNA Science), a company specializing in next-generation biotherapy, has achieved anti-CD19-CAR (chimeric antigen receptor) expression on human T cells through its proprietaryRead More…
Scientists Found a Novel Strategy to Resist T Cell Failure In CAR-T Cell Therapy
More and more cancer patients are receiving a promising new treatment called CAR-T cell therapy. In this treatment, the patient’s own T cells are removed from the body and genetically modified toRead More…
Scientists Reveal the Molecular Mechanism of CAR-T Cells in Anti-cancer Effect
Scientists have been hugely successful in developing a new type of anti-cancer therapy, immunotherapy, over the past decade, a treatment that attacks cancer cells by activating the body’s autoimmune system. One of theRead More…
One CAR-T Therapy Fights against Multiple Childhood Tumors
Scientists at Stanford University developed a new CAR-T therapy that can eradicate many types of childhood tumors in a mouse study, which was published in Clinical Cancer Research on January 17, furtherRead More…
CAR-T VS BsAb: A Comparative Analysis Based on Clinical Data from 2018 American Society of Hematology Annual Meeting
The unique advantages of CAR-T therapy in the treatment of hematological tumors have once again become a hot spot for the recent American Society of Hematology (ASH) Annual Meeting, and bispecific antibodiesRead More…
Blocking GM-CSF Protein Is Expected to Improve CAR-T Cell Therapy
In a new study, researchers from the Mayo Clinic in the United States have developed a new strategy that may improve the performance of chimeric antigen receptor T (CAR-T) cell therapy inRead More…
CAR-T cells Armored with Mini PD-1 Antibody Exhibit Stronger Anti-Tumor Efficacy
Recently, scientists from the Memorial Sloan Kettering (MSK) Cancer Center announced that they have established the latest engineered cells with powerful efficiency, which combine chimeric antigen receptor (CAR) -T cells and checkpointRead More…
Fights Cancer More Effectively——Supercharged Natural Killer Cell (CAR-iNKT)
Recently, a study conducted by the research team from the Imperial College London published in the Cancer Cell showed that supercharged natural killer (NK) cells capable of mass production can effectively fightRead More…