For many years, complement was viewed mainly as a circulating “attack system” that tags microbes and punches holes in their membranes. A recent review in the Journal of Clinical Investigation reframes thisRead More…
28Nov/25
15Sep/25
How to Enhance the Ability of Antibody Drugs to Activate Complement?
The complement system is recognized as one of the mechanisms by which antibody drugs function. However, early antibody drug design efforts rarely focused on enhancing complement activation. As research has progressed, strategies toRead More…
05Aug/25
Why is C1q Appearing in Every One of Your Topics?
Whether you’re studying autoimmune disorders, infectious disease models, tumor immunology, or neurodegeneration, C1q seems to show up in every figure legend, every mechanism diagram, and nearly every pathway conversation. So why isRead More…
01Jul/25
Complement-targeted Therapy: An Era of Blossoming Drugs
Complement and Cancer In 2007, the first truly complement-targeted drug, the anti-C5 monoclonal antibody eculizumab (Eculizumab, Soliris), was approved for the treatment of PNH, and has achieved a revolutionary success, not onlyRead More…
04Jun/25
Granzyme K-Mediated Complement Activation
The complement system has long been regarded as a fundamental component of innate immunity, with its three well-established activation routes—classical, lectin, and alternative pathways—serving as canonical pillars in immunology textbooks. However, aRead More…
07May/25
How Complement Proteins Influence Cancer Hallmarks
Cancer is a complex, multifactorial disease that evolves through a series of functional capabilities, widely known as the hallmarks of cancer. Among the numerous biological systems influencing these hallmarks, the innate immuneRead More…
02Apr/25
Targeting Complement C3: Unlocking Epitope-Specific Inhibition for Precision Immunotherapy
The complement system has long been recognized as a central player in innate immunity, defending the host against infections while maintaining tissue homeostasis. Among its components, complement C3 stands as a pivotalRead More…
13Feb/25
Complement-Dependent Cytotoxicity (CDC)
Although complement was originally described as a powerful defense mechanism against invading pathogens, it can also be activated by tumor-targeting antibodies to kill tumor cells. Antibody and Complement Activation Immunoglobulin (Ig) inductionRead More…
30Dec/24
Analysis of Drug Design Ideas for Complement Factor B Inhibitors
Complement factor B (CFB) inhibitors exert therapeutic effects by specifically binding to factor B, inhibiting abnormal activation of the complement bypass pathway, and controlling intravascular and extravascular hemolysis in paroxysmal sleep hemoglobinuriaRead More…
04Sep/24
Epigenetic and Transcriptional Changes in Complement Genes in Metabolic Dysfunction-Associated Steatosis Liver Disease
The complement system is an important component of innate immunity, playing a key role in defending against invading pathogens. It consists of approximately 60 soluble and membrane-bound proteins, including core components, receptors,Read More…