The complement system is an important component of innate immunity, playing a key role in defending against invading pathogens. It consists of approximately 60 soluble and membrane-bound proteins, including core components, receptors,Read More…
The increasing number of clinical diseases involving pathological contributions of the complement system has prompted renewed interest in therapeutic options to modulate this host defense pathway. Based on these findings, the pharmaceuticalRead More…
The human immune system’s most crucial element is the complement, and its two most essential subtypes are C3 and C4. Low levels of the two subtypes indicate that the immune system ofRead More…
Myasthenia gravis (MG) is an autoimmune disease characterized by an acquired neuromuscular junction transmission disorder mediated by autoantibodies. MG patients are mainly characterized by fluctuating weakness and fatigue of skeletal muscles, withRead More…
In 2013, experts reached a consensus to adopt the term C3 glomerulopathy (C3G) to define a group of rare kidney diseases driven by dysregulation of the alternative complement pathway, mediated by geneticRead More…
According to statistics, the prevalence of atypical hemolytic uremic syndrome (aHUS) is about seven in one million. The majority of aHUS have complement-related factor gene mutations, and the etiology of about 6%Read More…