Immuno-toxin Development Services for Cancer Immunotherapy

The Roles of Immunotoxin in Immunotherapy

An immunotoxin is a targeted therapy that combines a toxin with an antibody or cytokine to specifically target and kill certain cells. It specifically targets the cells of interest to minimize damage to healthy cells and reduce side effects. In recent years, significant progress has been made in the development of novel immunotoxins and their application in clinical trials. Advances in biotechnology and medicinal chemistry have allowed researchers to create more specific and potent immunotoxins, increasing the likelihood of successful treatment. As one of the leaders in antibody development and manufacturing, Creative Biolabs is committed to developing the next-generation immunotoxins, realizing more effective and safer immunotherapy. Our experts have extensive experience in the field of immunotoxin research and development, allowing us to design and manufacture novel immunotoxins that can effectively target specific cell types. From discovery to development and manufacturing, we are committed to delivering the next generation of targeted therapeutic agents.

Fig.1 The different generations of immunotoxin.¹

Immunotoxin Platform

At Creative Biolabs, we have developed an immunotoxin platform that utilizes the latest advances in protein engineering and structural biology to design and produce immunotoxins with improved specificity and efficacy. One of the key challenges in immunotoxin development is addressing the potential for off-target effects, which can lead to unwanted toxicity and adverse reactions. To minimize these risks, our platform focuses on the design of highly specific immunotoxins that bind to unique epitopes on the target cells. This approach ensures that the immunotoxin binds only to the intended target, reducing off-target toxicity. We provide comprehensive immunotoxin construction services including:

• Design of Targeting Molecules

Our scientists have experience in designing target moiety in immunotoxin constructs.

• Full-length antibodies or antibody fragments (Fab fragments, single-chain antibodies, or disulfide-stabilized Fv)
• Cytokines, growth factors, and chemokine receptor ligands

• Design of Linker

The choice of linkers is essential for the successful development of immunotoxins. The effective release of toxin domains in target cells can be achieved through the reasonable design of linkers with specific properties, thereby improving the therapeutic effect of immunotoxins.

• Design of Toxin Domains

Proteinaceous toxins from microorganisms, plants, insects, and vertebrates have been used in immunotoxin constructs.

• Bacterial toxins: Diphtheria toxin, Pseudomonas exotoxin, calicheamicin, etc.
• Plant toxins: ricin, Saporin-S6, pokeweed antiviral protein, gelonin, etc.
• Animal toxins: human proapoptotic proteins

Our Capabilities

• Cutting-edge genetic engineering and conjugation techniques to create novel immunotoxins
• Expertise in designing and optimizing immunotoxins
• State-of-the-art production processes and purification techniques to ensure the quality of immunotoxins
• Extensive experience and professional support to offer valuable guidance

Work with Creative Biolabs

Reference

1. Rust, Aleksander, et al. "The use of plant-derived ribosome-inactivating proteins in immunotoxin development: Past, present and future generations." Toxins 9.11 (2017): 344.

For Research Use Only | Not For Clinical Use