Based on the unrivaled expertise and experiences in immune-oncology, Creative Biolabs is dedicated to providing end-to-end service from discovery to commercialization to accelerate our customers' biopharmaceutical development pipeline and mechanism research for customers.
During the past decade, the involvement of the microbiome-immune interactions between gut and brain has become the focus of many scientists, setting the microbiota-gut-brain axis as an area of research. A growing number of related studies are exploring the possible roles of microbiota-gut-brain axis in memory, learning, stress, neurodevelopmental and neurodegenerative disorders.
The gut-brain axis (GBA) involves two-way communication between the central and the enteric nervous system, linking the brain’s emotional and cognitive centers to peripheral intestinal functions. The gut microbiota can influence the maturation and function of immune system that subsequently changes the brain and behavior activity. Mucosal immune response promotes the establishment of the intestinal microbiome by mediating host-microbe symbiosis, and influences immune activities such as antibody production and T cell numbers. These host-microbe interactions can alter immunity in the brain, affecting the maturation and activation of microglia and astrocytes. In addition, the resident brain cells and peripheral immune cells play a key role in MGB axis communication, with signal loss leading to inflammatory disease and impaired neurogenesis in the central nervous system. In summary, the communications of microbiota-immune interactions: gut-brain axis play an important role in maintaining homeostasis.
Fig.1 Pathways of immune signaling regulating the microbiota-gut-brain axis. (Salvo-Romero, 2020)
Experienced in immuno-oncology research, Creative Biolabs has robustly developed in vitro and in vivo platforms to provide reproducible custom assays for our clients all over the world. We are dedicated to designing comprehensive research practices and handling high-quality studies to support your biopharmaceutical development pipeline.
Creative Biolabs’ scientists are dedicated to bringing together years of valuable experience to help our clients shorten the project journey. For more detailed information, please feel free to contact us or directly sent us an inquiry.
Reference
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