Brain-Immune-Gut Based Integrative Research

As a pioneer and the undisputed global leader in brain-immune-gut based integrative research, Creative Biolabs is confident in providing an integrated solution for brain-immune-gut based integrative research to best suit your program requirements.

The Importance of Brain-Immune-Gut Based Integrative Research

Over the past few decades, the incidence of mental disorders and neurological diseases has increased. There are a lot of studies that are starting to focus on neurological diseases, and the study of brain-immune-gut has become a relatively hot topic. Research on the brain-immune-gut axis has shown that the gut microbiome plays a crucial role in modulating the development and function of tissue-resident immune cells as well as peripheral immune cells; regulating brain development and behavior, while the immune system plays an important regulator role in these interactions. Taken together, the cross-talk communication of the gut microbiota and the immune system, as well as these signal networks, are associated with the pathogenesis of neurodevelopmental, psychiatric, and neurodegenerative diseases. Therefore, studying this axis is of great significance currently.

Fig.1 The ever-increasing medical burden induced by mental disorders and neurological diseases. (Liang, 2018)

The Background of the Brain-Immune-Gut Axis

The brain-immune-gut axis mainly includes the neural pathways, endocrine pathway, and immune pathway. Among them, the neural pathway is accompanied by items of neural conduction, neurotransmitters, neurogenesis, nerve cell apoptosis, and neurodegeneration. The endocrine pathway mainly functions through the neuroendocrine system, neurohormones, and neuroactive substances. The third pathway: the immune pathway mainly operates through the regulation of innate, adaptive immunity, and peripheral, neural inflammation. Altogether, information transmitted along the microbiota-gut-brain axis is integrated into the brain, gut-brain, and these three pathways, regulating responses to neuroinflammation, brain injury, autoimmunity, and neurogenesis.

Fig.2 The gut-brain communicates with the brain mainly via three pathways of the microbiota-gut-brain axis. (Liang, 2018)

Working with Creative Biolabs

Creative Biolabs has robustly developed, optimized, and validated the integrated study platform. We are committed to providing custom brain-immune-gut based integrative study assay portfolio services, from which you can select the best fit for your specific project. We are focused on the following research topics:

Brain-Immune-Gut Interaction Study
Microbiota-immune interactions: Gut-Brain Axis Microbiota-Immune Interactions and CNS Alterations Probiotics on Central Nervous System Functions Neuroscience Assays Isolation, Culture, and Characterization Service of Neural Cells In Vitro Analysis of Human Brain Cells

Gut Microbiota in Therapeutic and Diagnostic Research
Targeted Monitoring of Gut Microbiota Gut Microbiota Engineering Service

Gut Microbiota and Neuro Diseases (Project Study)
Non-Human Animal Model Construction Tumor Assessment and Tissue Preparations Determination of the Relative Abundances of L. Reuteri, hdc Genes, and mRNA In Vivo Neurotransmitters-Related Molecular Measurement System Immunity Measurement Cytokine Measurement Modulation of Mammalian Cytokine Gene Expression in the Colonic Mucosa

Creative Biolabs’ scientists are dedicated to bringing together years of valuable experience to help our clients shorten the research journey. For more details on our brain-immune-gut based integrative research, please feel free to contact us to learn how we can be involved in your project.

References

Liang, S.; et al. Gut-brain psychology: rethinking psychology from the microbiota-gut-brain axis. Frontiers in integrative neuroscience. 2018, 11,12:33.
Fung, T.C.; et al. Interactions between the microbiota, immune and nervous systems in health and disease. Nature neuroscience. 2017, 20(2):145-55.

For Research Use Only | Not For Clinical Use