Based on profound expertise and first-class techniques, Creative Biolabs has developed several services related brain-Immune-gut based integrative studies for global clients to speed up the project’s development.
In the brain-immune-gut interaction study, intervention is an important research topic, where probiotics have proven to be a promising intervention option for central nervous system (CNS) disorders. Probiotics are defined as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”. Usually, studies have used certain types of probiotics to treat gastrointestinal disorders, such as irritable bowel syndrome (IBS). Meanwhile, in the past decades, probiotics have been reported to influence the CNS function by altering gut microbiota composition. Several studies have used probiotics to modify the MGB axis, improve behavior related to stress-related psychiatric conditions, improve memory abilities, and induce neuronal plasticity.
Fig.1 Therapeutic interventions targeting the microbiota-immune axis in CNS disorders. (Fung, 2020)
Probiotics affect central nervous system function through both direct and indirect mechanisms. Probiotics influence the hypothalamic-pituitary-adrenal (HPA) axis by changing the level of corticosteroid (CORT), adrenocorticotropic hormone (ACTH). The immune system is influenced by the limited production of pro-inflammatory cytokine and inflammation, which in turn affects the central nervous system. Also, probiotics can directly change the biochemistry of CNS, for example by affecting the levels of brain-derived neurotrophic factor (BDNF), c-Fos, and dopamine (DA), thus affecting brain and behavior. Additionally, probiotics modulate the gut microbiota (GM) by increasing the diversity and composition of beneficial bacteria.
Fig.2 Mechanisms of probiotic effects on the central nervous system. (Wang, 2016)
Since several types of neurological disorders have been identified, including neurodegenerative defects, psychiatric disorders, post-trauma related disorders. It is an urgent research work to evaluate the appropriate probiotic mixture for specific diseases and patient populations. In addition, the viability of each strain and commercialized product to remain enough numbers and high bioavailability at the target site needs to be considered.
Creative Biolabs’ scientists are dedicated to bringing together years of valuable experience to help our clients shorten the clinical study journey. We are committed to providing tailored services to each project to ensure that the objectives are met or exceeded. For more details on brain-immune-gut based integrative service, please don't hesitate to contact us to learn how we can be involved in your project.
References
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