NHP Based Pharmacology and Pharmacodynamics Service
Services Published Data FAQ Customer Review Related Services and Products
Services
Following closely the industrial development trend, Creative Biolabs offers comprehensive non-human primate (NHP) based pharmacology and pharmacodynamics (PD) services to accelerate global researchers' projects. Our dedicated team has decades of experience in drug development. Whether you desire an integrated preclinical service or a stand-alone pharmacology and pharmacodynamics research, we have the confidence to get your research to succeed with our comprehensive NHP platform.
NHP Based In Vitro Pharmacology Service
Creative Biolabs has established a mature NHP-based in vitro pharmacology platform and can provide our global customers with enough space to choose the type of service they desire. We have optimized the protocol for every research category and will ensure the precision and reliability of data for your project.
Types of in vitro pharmacology services
| Research Type | Purpose | Description |
|
Evaluation of immunostimulatory effect | Analyze the release course of relevant cytokines through the immunoassays based on monkey whole blood and PBMCs. |
| Assessment of the effect on drug metabolism | Utilize primate liver microsomes or primary hepatocytes to test the potential inhibitory effect of drugs on CYP 450 enzymes. | |
| Explore the effect on drug transporters | Exploit primary monkey cells to test the potential inhibitory effect of drugs on ABC drug transporters. |
NHP Based In Vivo Pharmacodynamics (PD) Service
At Creative Biolabs, we are deeply aware of the significance of in vivo PD research for bridging your preclinical studies and clinical applications. Based on multiple species of NHPs and years of experience, we have put efforts into establishing the NHP-based in vivo PD platform. To date, we have launched a series of service types to help you conduct the PD study based on biomarkers related to genes, small molecules, and proteins through our validated non-human primate models. You can also obtain high-quality cellular, histologic, and immunologic phenotyping analysis data from our extensive services.
Types of NHP-based in vivo PD service
| Research Type | Purpose | Description |
|
Assessment of systemic biomarker level during pharmacokinetic study | The biomarker levelin the systemic circulation is measuredduring the PK study. |
| Evaluation of systemic biomarker level through a specially designed experiment | The biomarker level in the systemic circulation is measured through a well-designed experiment. | |
| Explore the systemic level of biomarkers affecting efficacy and safety | Efficacy and biomarker levels are measured by multiplex assays during the PK study. | |
| Study the tissuespecificityor biomarker levelsthrough a confirmatory experimental design | The biomarker levels in the different tissues are measured during the clinical pharmacology or toxicology study. | |
| Analyze the tissue distribution of biomarkers during pharmacokinetic study | Specific tissues and fluids are obtained by biosampling, biopsy, or microdialysis to measure the biomarker level during the PK study. |
Why Partner with Creative Biolabs
Creative Biolabs has been adhering to technology innovation and the improvement of service quality since its inception, which has won numerous positive comments from global clients. With a professional scientific team, we're confident to bring you a smooth drug development experience.
In addition to pharmacology and pharmacodynamics services, Creative Biolabs also offers other NHP-based research services for your preclinical program. Welcome to contact us for more service details.
- Biospecimen Custom Collection Service
- NHP Based Pharmacokinetics Service
- NHP Based Safety Assessment Service
- NHP Based Gene Therapeutics Development Service
- NHP Based Biomarker Discovery and Validation Service
- NHP Based Method Development and Validation Service
Published Data
The article delves into the unique and significant role of non-human primates (NHPs) in central nervous system (CNS) safety pharmacology. The study provides experimental evidence demonstrating the superior translational value of NHP models compared to rodents, particularly in assessing the safety and behavioral effects of CNS drugs, such as antipsychotics.
Key experimental findings include the observation that classical antipsychotics like haloperidol, in contrast to atypical antipsychotics such as clozapine, induce behavioral signs in NHPs that closely parallel human responses. This is not the case with rodent models, highlighting the higher translational value of NHPs. The research utilized both operant and non-operant techniques to assess the cognitive impacts of drugs in NHPs, underscoring the closer anatomical and functional similarities of NHP brain structures to humans.
Further, the study explored drug-induced behavioral symptoms like sedation, drowsiness, excitation, and aggression in NHPs, noting these responses are more readily recognizable and comparable to human reactions. This includes examining phenomena such as extrapyramidal symptoms (EPS) induced by antipsychotics, providing invaluable insights into the safety profiles of these drugs. Such findings reinforce the argument for the use of NHPs in CNS and other safety pharmacology areas, given their higher translational validity and relevance compared to rodent procedures.
This research emphasizes the importance of NHPs in pharmacological research, particularly for understanding the complex interactions of CNS drugs, and highlights their crucial role in bridging the gap between preclinical studies and human clinical trials.
Fig. 1. Acute dystonic effects induced by different antipsychotics in primed rhesus monkeys compared with their general sedative effects. N = 4. Data from Porsolt and Jalfre (1981).
FAQ
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How are side effects managed in NHP pharmacology studies?
Understanding and managing side effects is a crucial aspect of NHP pharmacology and pharmacodynamics. Most drugs can cause unwanted side effects in addition to their intended action, even when administered at recommended doses. This is particularly important in NHP studies as these models are often used to predict human responses. Researchers must have a deep understanding of pharmacokinetics and pharmacodynamics to anticipate and mitigate adverse drug reactions. This involves identifying medicines and patient groups at increased risk, understanding the mode of action of drugs, and applying this knowledge to prevent harmful interactions and side effects. -
What are common compliance issues in pharmaceutical research involving NHP?
Compliance with regulatory standards is a significant concern in pharmaceutical research, including studies involving NHP. Common issues include inadequately documented Standard Operating Procedures (SOPs), insufficient records of cGMP (current Good Manufacturing Practice) training, and failures in laboratory controls. These issues can lead to noncompliance with regulatory requirements, affecting the reliability and safety of pharmaceutical products. Ensuring scientifically sound lab controls, proper maintenance of equipment, and effective SOPs are essential for compliance and quality assurance in pharmaceutical research.
Customer Review
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Dr. Elizabeth Grant, Senior Pharmacologist.
We approached Creative Biolabs for their expertise in NHP Based Pharmacology, focusing on CNS drug safety. Their approach, employing NHP models, provided us with critical insights into the behavioral and cognitive effects of our CNS drug candidates. The similarities observed between NHP and human responses greatly enhanced our confidence in the translational value of our research. This collaboration not only advanced our understanding of the drug's safety profile but also reinforced our commitment to developing safer CNS therapeutics.
Related Services and Products
- NHP Based Method Development and Validation Service
- NHP Based Biomarker Discovery and Validation Service
- NHP Based Gene Therapeutics Development Service
- NHP Based Safety Assessment Service
- NHP Based Pharmacokinetics Services
- NHP Biospecimen Custom Collection Service
Reference
- Roger D. Porsolt., et al. " The usefulness of non-human primates in central nervous system safety pharmacology." Journal of Pharmacological and Toxicological Methods 68 (2013) 004
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