Multiple myeloma is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, in a recent study published in Science Translational Medicine entitled “Selective targeting of multiple myeloma cellsRead More…
Nuclear envelope (NE) consists of outer nuclear membrane (ONM) and inner nuclear membrane (INM), which are separated by the perinuclear space and connected at the nuclear pore complex. Inner nuclear membrane proteinsRead More…
Recently, a research paper entitled “Structural insights into the membrane microdomain organization by SPFH family proteins” was published in Cell Research. The high-resolution structure of super membrane complexes formed by two representativeRead More…
Under the COVID-19 pandemic, the crisis of long-standing and equally deadly infectious diseases remains unabated. Although the death rate in 2020 is still being calculated, more than 400,000 people die from malariaRead More…
Vascular dysfunction contributes to the pro-oncogenic tumor microenvironment and impedes the delivery of therapeutic drugs, so normalizing tumor blood vessels may become a potential path. Scientists have developed a new type ofRead More…
In a new study, researchers from the University of Utah, Rockefeller University, and Pennsylvania State University determined how CHMP3 variants (RetroCHMP3) discovered in mice and monkeys interfere with the replication of envelopedRead More…
The identification of drug resistance mutations in drug targets provides vital information for new drug development. Due to the fallibility of HIV-1 reverse transcriptase (RT), lentivirus transduction can lead to many typesRead More…
Lipid rafts are microstructural domains packed tightly in the plasma membrane and rich in cholesterol and sphingomyelin, which play an important role in many pathophysiological processes. Previously, researchers thought that the lipidRead More…
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is still spreading, with devastating consequences for human life and global economic mortality and morbidity. SARS-CoV-2 is transmitted between infectedRead More…
Deubiquitination Enzyme Regulates the Biosynthesis of Membrane Proteins Many proteins with hydrophobic transmembrane domain (TMD) can transfer from cytoplasm to cell membrane after translation. However, it is not clear how hydrophobic membraneRead More…