The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is still spreading, with devastating consequences for human life and global economic mortality and morbidity. SARS-CoV-2 is transmitted between infectedRead More…
Deubiquitination Enzyme Regulates the Biosynthesis of Membrane Proteins Many proteins with hydrophobic transmembrane domain (TMD) can transfer from cytoplasm to cell membrane after translation. However, it is not clear how hydrophobic membraneRead More…
3 Relationship Between CD47-related Signaling Pathways and Diseases 3.1 Cancer CD47 is highly expressed on the surface of many kinds of tumor cells, which, as a signal molecule of “don’t eat me”,Read More…
2 CD47-related Signaling Pathways The extracellular ligands interacting with CD47 are TSP1, SIRP α, and CD47 itself. Among them, little is known about the signal transduction involved in the homotypic interaction ofRead More…
Cluster of differentiation 47 (CD47) is a widely expressed glycoprotein on the cell surface, which can interact with a variety of intracellular and extracellular proteins such as thrombospondin-1 (TSP-1) and signal regulatoryRead More…
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, theRead More…
In a new study, an international team led by the University of Bonn identified and further developed the novel single-domain antibodies (sdAbs) against SARS-CoV-2. The researchers also combined these single-domain antibodies intoRead More…
In a recent study, the scientists at UT Southwestern have developed a new method to study the molecular characteristics of T cells. The method, published on Nature Methods, makes it easier forRead More…
Recently, the phase 3 clinical trial results of T cell receptor (TCR) therapy, tebentafusp, have been released. The results showed that it reached the primary endpoint in the treatment of metastatic uvealRead More…
A new study published on eLife shows when T cells in the immune system find and identify targets, they release chemicals to attract more T cells, and then gather to help suppressRead More…