3 Relationship Between CD47-related Signaling Pathways and Diseases 3.1 Cancer CD47 is highly expressed on the surface of many kinds of tumor cells, which, as a signal molecule of “don’t eat me”,Read More…
CD47-related Signaling Pathways & Research Progress on the Relationship with Related Diseases (Part Two)
2 CD47-related Signaling Pathways The extracellular ligands interacting with CD47 are TSP1, SIRP α, and CD47 itself. Among them, little is known about the signal transduction involved in the homotypic interaction ofRead More…
CD47-related Signaling Pathways & Research Progress on the Relationship with Related Diseases (Part One)
Cluster of differentiation 47 (CD47) is a widely expressed glycoprotein on the cell surface, which can interact with a variety of intracellular and extracellular proteins such as thrombospondin-1 (TSP-1) and signal regulatoryRead More…
Sci Rep: Monoclonal Antibody can Effectively Treat Malaria
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, theRead More…
Multivalent Single Domain Antibodies Help Block SARS-CoV-2 Infection and Suppress Mutational Escape
In a new study, an international team led by the University of Bonn identified and further developed the novel single-domain antibodies (sdAbs) against SARS-CoV-2. The researchers also combined these single-domain antibodies intoRead More…
Nat Methods: How to Enhance the Effect of T Cell Therapy?
In a recent study, the scientists at UT Southwestern have developed a new method to study the molecular characteristics of T cells. The method, published on Nature Methods, makes it easier forRead More…
New TCR Therapy—Tebentafusp
Recently, the phase 3 clinical trial results of T cell receptor (TCR) therapy, tebentafusp, have been released. The results showed that it reached the primary endpoint in the treatment of metastatic uvealRead More…
eLife: The New Anticancer Mechanism of T Cells
A new study published on eLife shows when T cells in the immune system find and identify targets, they release chemicals to attract more T cells, and then gather to help suppressRead More…
The Discoverers of Hepatitis C Virus Won the 2020 Nobel Prize in Physiology or Medicine
The 2020 Nobel Prize in Physiology or Medicine is awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus”. Thanks to their discovery,Read More…
COVID-19 May Lead to the Loss of Important Immune Structure—It Is Expected to Explain the Cause of Secondary Infection in Recovered Patients
According to the latest report from the Science, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients who died of COVID-19 and found thatRead More…