Deubiquitination Enzyme Regulates the Biosynthesis of Membrane Proteins Many proteins with hydrophobic transmembrane domain (TMD) can transfer from cytoplasm to cell membrane after translation. However, it is not clear how hydrophobic membraneRead More…
3 Relationship Between CD47-related Signaling Pathways and Diseases 3.1 Cancer CD47 is highly expressed on the surface of many kinds of tumor cells, which, as a signal molecule of “don’t eat me”,Read More…
2 CD47-related Signaling Pathways The extracellular ligands interacting with CD47 are TSP1, SIRP α, and CD47 itself. Among them, little is known about the signal transduction involved in the homotypic interaction ofRead More…
Cluster of differentiation 47 (CD47) is a widely expressed glycoprotein on the cell surface, which can interact with a variety of intracellular and extracellular proteins such as thrombospondin-1 (TSP-1) and signal regulatoryRead More…
According to the latest report from the Science, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients who died of COVID-19 and found thatRead More…
Researchers from Charité-Universitätsmedizin Berlin, Berlin Institute of Health and Deutsches Rheuma-Forschungszentrum, together with other scientists, have shown how microbes help the immune system respond to pathogens. Without the relevant mediators, the metabolicRead More…
Researchers at Harvard University studied the common cold for clues to how the COVID-19 virus might behave. They used close relatives of SARS-CoV-2 to simulate its behavior in the coming months. TheRead More…
B lymphocytes can only produce a proprietary antibody against an antigen determinant, so it has the characteristics of highly specific physical and chemical properties, single biological activity, strong binding specificity with antigenRead More…
The Antibodies are secreted by plasma cells transformed from B cells, and each B cell line can produce only one specific antigenic determinant. The antibody, produced from a single cell line, isRead More…
Alzheimer’s disease (AD) is a neurodegenerative disease common in the elderly. The main pathological changes were diffuse atrophy of cerebral cortex, neurofibrillary tangles and the formation of a large number of senileRead More…