On May 17, 2018, the U.S. Food and Drug Administration approved erenumab-aooe (Aimovig) for the preventive treatment of migraine in adults. Erenumab is a human monoclonal antibody that targets calcitonin gene-related peptide (CGRP) receptor,Read More…
Immunotherapy with checkpoint inhibitors is more effective in cancer patients who have elevated numbers of specific types of immune cells inside their tumors, a study suggests. Patients with a favorable combination of immuneRead More…
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy. Researchers trying to develop new treatments, or even aRead More…
Unlike the mechanism of action of traditional treatments, immunotherapy is uniquely characterized by its long-term response and survival in efficacy, unconventional delayed response and pseudo-progression in response mode, a new assessment endpointRead More…
In the process of discovering monoclonal antibodies, after screening antibody libraries to obtain excellent candidate molecules that can specifically bind to targets, it is necessary to enhance certain pharmacological and other functionsRead More…
In a groundbreaking study, researchers from the Genome Institute of Singapore (GIS) developed a new computer model of machine learning (an artificial intelligence model, AI) to accurately find tumor mutations. They alsoRead More…
Most proteins have a tendency to form polymers, which are accompanied by slow polymer formation when they are produced, stored, transported, and injected into a patient. There are two reasons for whyRead More…
Monoclonal antibodies (mAbs) — preparations of a specific type of antibody designed to bind to a single target — have shown promise in the fight against cancer and autoimmune diseases. They alsoRead More…
Model of Factor VIII. © 3d ribbon/surface model of the human factor VIII after PDB 3CDZ. Ref.: Ngo JC, Huang M, Roth DA, Furie BC, Furie B (April 2008). DOI:10.1016/j.str.2008.03.001. Roche’s USRead More…
“Two new studies use new models to identify genetic targets and test promising treatments for adrenal cancer. One patient was treated with the immunotherapy pembrolizumab and now more than a year afterRead More…