The International Union Against Cancer believes that one-third of cancers are preventable, one-third can be cured if diagnosed early, and one-third can be alleviated to help prolong patients’ life. Cancer control isRead More…
First Approval for Erenumab
On May 17, 2018, the U.S. Food and Drug Administration approved erenumab-aooe (Aimovig) for the preventive treatment of migraine in adults. Erenumab is a human monoclonal antibody that targets calcitonin gene-related peptide (CGRP) receptor,Read More…
Combination of Immune Cells Improves Chances of Successful Immunotherapy
Immunotherapy with checkpoint inhibitors is more effective in cancer patients who have elevated numbers of specific types of immune cells inside their tumors, a study suggests. Patients with a favorable combination of immuneRead More…
“Public” T-Cell Receptors from Resistant People Fend Off HIV
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy. Researchers trying to develop new treatments, or even aRead More…
Overview on Characteristics of Tumor Immunotherapy
Unlike the mechanism of action of traditional treatments, immunotherapy is uniquely characterized by its long-term response and survival in efficacy, unconventional delayed response and pseudo-progression in response mode, a new assessment endpointRead More…
Common Engineering Techniques and Strategies in Antibody Discovery
In the process of discovering monoclonal antibodies, after screening antibody libraries to obtain excellent candidate molecules that can specifically bind to targets, it is necessary to enhance certain pharmacological and other functionsRead More…
Nat Commun: Artificial Intelligence Helps Find Gene Mutations That Cause Gastric Cancer
In a groundbreaking study, researchers from the Genome Institute of Singapore (GIS) developed a new computer model of machine learning (an artificial intelligence model, AI) to accurately find tumor mutations. They alsoRead More…
What You Should Know about Antibody Monomer
Most proteins have a tendency to form polymers, which are accompanied by slow polymer formation when they are produced, stored, transported, and injected into a patient. There are two reasons for whyRead More…
Monoclonal Antibodies Crucial to Fighting Emerging Infectious Diseases
Monoclonal antibodies (mAbs) — preparations of a specific type of antibody designed to bind to a single target — have shown promise in the fight against cancer and autoimmune diseases. They alsoRead More…
Roche Reports 5 Deaths After Dosing of Hemlibra
Model of Factor VIII. © 3d ribbon/surface model of the human factor VIII after PDB 3CDZ. Ref.: Ngo JC, Huang M, Roth DA, Furie BC, Furie B (April 2008). DOI:10.1016/j.str.2008.03.001. Roche’s USRead More…