This program aims to develop c-MET x CTLA-4 therapeutic bispecific antibody for non-small-cell lung cancer immunotherapy.
Rationale for our program:
c-MET is a high-affinity receptor that binds to hepatocyte growth factor (HGF). Up-regulation of c-MET expression contributes to the promotion of tumor progression, invasion, metastasis and angiogenesis in different types of solid tumors, including NSCLC. In addition, studies have shown that activation of the HGF/c-MET pathway in solid tumors can stimulate lymphangiogenesis, leading to lymph node metastasis. Currently, c-MET inhibitors have entered Phase II clinical trials for the treatment of patients with hepatocellular carcinoma. However, these c-MET inhibitors are closely related to potential side effects. Therefore, it is necessary to develop new types of therapies.
CTLA-4 is a negative regulator of important T cell responses leading to T cell failure. T cell dysfunction occurs in many types of cancer, so blocking CTLA-4 may provide promising therapies for anti-tumor T cell immunity. Currently, there is no mAb blocking CTLA-4 in NSCLC.
The following data support the rationale for the development of c-MET x CTLA-4 BiAbs with an improved therapeutic index for the treatment of NSCLC.
(Li, 2019)
The global NSCLC drug market is expected to post a CAGR of more than 13% during the period 2019-2023.
The global NSCLC drug market is expected to increase by more than $25 billion between 2018 and 2026.
Clinical efforts of target therapy to date have failed to demonstrate widespread efficacy and are associated with severe toxicity. Therefore, immunotherapy will represent the next generation NSCLC treatment.
NCT ID | Status | Conditions | Lead Sponsor | Phase | Update Time |
NCT04077463 | Recruiting | Carcinoma, Non-Small-Cell Lung | Janssen Pharmaceutical K.K. | Phase 1 | September 17, 2019 |
Creative Biolabs has extensive knowledge of end-to-end program development. For each program, we are committed to delivering the final complete program to our clients within 1.5 years before entering the IND stage.
Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop c-MET x CTLA-4 therapeutic bispecific antibody program together. Our scientists are dedicated to bringing years of valuable experience to our partner and achieve a meaningful partnership together. For any partners interested in our Next-IO™ programs, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from the discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate for our programs.
With our quality control protocol and knowledge of global regulatory requirements, we can help our partners further their programs with more chances to succeed. Look forward to cooperating with you in the near future.
For Research Use Only | Not For Clinical Use