CCR5 Assay Portfolio Service
Creative Biolabs offers a specialized C-C chemokine receptor type 5 (CCR5) assay portfolio service to support targeted cancer therapy and diagnosis. We utilize advanced technologies and experienced scientists to precisely assess the CCL5/CCR5 axis. This signaling pathway is often abnormally active in both hematological malignancies and a wide range of solid tumors, promoting progression and metastasis. Our service provides the reliable data necessary to characterize this axis, supporting its use as a diagnostic biomarker and facilitating the development of novel CCR5-targeting therapeutic strategies.
Background What We Can Offer Publication Why Choose Us FAQs Customer Review Related Services Contact Us
The Central Role of CCR5 in Disease Pathophysiology
CCR5 is a G-protein-coupled receptor that binds multiple ligands and is highly expressed in various cancers. Its activation promotes cell survival, proliferation, and migration. The CCL5/CCR5 axis is particularly important in cancer, as CCL5 secreted by tumor cells increases tumor growth and induces collagen degradation, and also promotes cell migration and invasion. This axis also recruits normal cells to the tumor microenvironment (TME) and induces the immunosuppressive polarization of monocytes and myeloid cells, leading to M2-TAMs and MDSCs, which in turn cause the exhaustion of effector T-cells. Additionally, CCR5 expression is associated with stronger DNA damage repair responses and can decrease the cytotoxic activity of drugs.
Creative Biolabs' CCR5 Assay Portfolio: Precision and Expertise
Our expertise is rooted in providing a versatile and customizable platform, ensuring that your unique project specifications are met with a scientifically rigorous approach. We specialize in:
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Publication
This review explores the critical and dual role of the CCL5/CCR5 chemokine axis in cancer progression and the TME. The authors detail how this axis is hijacked by cancer cells to promote tumor growth, metastasis, immune evasion, and treatment resistance. Key mechanisms include recruiting immunosuppressive cells, promoting angiogenesis, and enhancing cancer stem cell properties. The review highlights the therapeutic potential of targeting this pathway, particularly with the repurposed CCR5 antagonist maraviroc, which has shown promising preclinical results. The work establishes the CCL5/CCR5 axis as a central regulator of the pro-tumorigenic TME and a promising frontier for cancer immunotherapy.
Fig.1 The CCL5/CCR5 axis in cancer progression. 1
Why Choose Us?
Creative Biolabs stands out as a leader in G protein-coupled receptor (GPCRs) and oncology-focused assay development. Our expertise is not limited to standard binding assays; we possess a deep understanding of the complex signaling pathways and functional roles of CCR5 in diseases like cancer. We offer a comprehensive and highly customizable portfolio, ensuring that we can tailor our services to your unique research questions. Our commitment to quality and reproducibility means you can trust the data we provide, allowing you to make critical decisions with confidence.
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FAQs
Q1: How can your assays help me develop combination therapies?
A1: Our functional assays can be designed to evaluate how your CCR5 antagonist works in concert with other agents, such as chemotherapy drugs or immune checkpoint inhibitors. We can provide data on synergistic effects and help you optimize your combination strategy.
Q2: What is the sensitivity of your assays
A2: Our assays are designed to be highly sensitive and specific, capable of detecting the binding and functional activity of both high-affinity and low-affinity compounds. This ensures no promising candidates are missed during the screening process.
Q3: Can you work with genetic variants of the CCR5 gene
A3: Yes, we can develop assays specific to various genetic variants. This is particularly important for projects focused on personalized medicine, as it allows for the stratification of patient populations.
Customer Review
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Elucidated Chemoresistance
Creative Biolabs' services significantly improved our understanding of this axis's role in chemoresistance. Their expertise in developing assays for these pathways provided critical data, which gave us a clearer path for our combination therapy strategy. – Aa*Rs
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Uncovered Novel Scaffolds
Using Creative Biolabs' platform has significantly improved our ability to screen large compound libraries efficiently. Their high-throughput screening platform identified several novel scaffolds that showed strong antagonist activity. – Sh*Kr
Related Services
In addition to our core CCR5 assay portfolio service, Creative Biolabs offers several complementary services that can help you achieve your project goals.
Functional Genetic Screening Services for Tumor Metabolism
Creative Biolabs provides a first-class platform for functional genetic screening for tumor metabolism. We explore the functional characteristics of metabolic genes and enzymes to aid in early cancer diagnosis and therapeutic research.
Learn More →
CCR Panel Screening Service
Creative Biolabs provides comprehensive cellular functional selectivity panels, including a chemokine receptor (CCR) panel screening service, to explore the therapeutic potential of GPCRs.
Learn More →
Contact Us
Creative Biolabs is your trusted partner for CCR5 therapeutic development. Our comprehensive, customizable services and deep scientific expertise are designed to accelerate your drug discovery journey. We provide not just data, but actionable insights to help you succeed.
Contact Our Team for More Information and to Discuss Your Project.
Reference
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Aldinucci, Donatella, Cinzia Borghese, and Naike Casagrande. "The CCL5/CCR5 axis in cancer progression." Cancers 12.7 (2020): 1765. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/cancers12071765
