CD123 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs delivers comprehensive solutions for target validation, lead optimization, and preclinical/clinical biomarker analysis. Clients can expect validated data on CD123 expression, receptor occupancy, internalization kinetics, and functional impact, all tailored to their specific therapeutic modalities, including antibody-drug conjugates (ADCs), bispecific antibodies, and CAR T-cell therapies. Creative Biolabs helps you confidently advance your CD123-targeted programs, from initial discovery to regulatory submission.
The Biology of CD123
CD123, also known as interleukin-3 receptor α (IL-3Rα), is a type I transmembrane glycoprotein. CD123 is expressed in basophils, dendritic cells, monocytes, myeloid progenitors of normal hematopoietic cells, and endothelial cells, to induce tyrosine phosphorylation, proliferation, and differentiation within a cell. CD123 antigen facilitates the transmission of the signal of IL-3, an important soluble cytokine in the immune system. CD123 antigen is highly expressed on a variety of cells from many hematologic malignancies. Therefore, CD123 has emerged as an attractive immunotherapeutic target for the treatment of CD123 hematologic malignancies.
Discover how we can help - Request a consultation.
Fig.1 Schematic diagram of various CD123-targeted therapeutic constructs.1
What We Can Offer
|
CD123 Expression and Characterization Assays
|
Functional Assessment of CD123-Targeted Therapies
|
-
ELISA assay
-
Flow Cytometry
-
Immunoblotting
-
Immunofluorescence and Immunohistochemistry
|
-
Apoptosis assay
-
CD123 blockade assay
-
Cell differentiation assay
-
Cell proliferation assay
-
Cytotoxicity assay
|
Workflow of CD123 Assay Portfolio Service
Highlights
Unrivaled Expertise
Creative Biolabs possesses an unparalleled understanding of CD123 biology and its implications in hematological malignancies. Our seasoned scientists provide expert guidance.
Cutting-Edge Technology
We continuously invest in state-of-the-art analytical platforms, including advanced multi-parameter flow cytometers, high-resolution imaging systems, and automated liquid handling systems.
Uncompromising Quality & Reproducibility
Every assay adheres to stringent quality control measures and standardized protocols, guaranteeing high data integrity and reproducibility. Our meticulous validation processes and consistent calibration minimize variability.
Tailored & Flexible Solutions
We offer highly flexible, tailored solutions for each unique project. Our team works closely with you to customize every aspect, from experimental design to data analysis.
Experience the Creative Biolabs advantage - Get a quote today.
Customer Reviews
-
Exceptional Precision
Using Creative Biolabs' CD123 assay portfolio service in our research has significantly improved the precision of our CD123 expression quantification. Their flow cytometry data is consistently reliable, which is crucial for our therapeutic development. - Dr. Jn Sh.
-
Streamlined Target Validation
The functional assays provided by Creative Biolabs' CD123 assay portfolio service facilitated our target validation efforts immensely. We were able to quickly assess the anti-proliferative effects of our novel CD123-targeting agent, saving us months of development time. - Dr. Aa Kr.
FAQs
How do Creative Biolabs' CD123 assays ensure high sensitivity and specificity for rare cell populations?
We utilize advanced multi-parameter flow cytometry and highly optimized antibody panels, coupled with rigorous gating strategies and robust data analysis. This allows for precise detection and quantification of CD123 expression even on rare leukemic stem cells or minimal residual disease populations, ensuring the highest sensitivity and specificity for your research.
Can your service accommodate unique or challenging sample types?
Absolutely. Our team has extensive experience working with a wide range of biological samples, including peripheral blood and various cell lines. We employ optimized protocols for sample handling and preparation to maintain cell viability and antigen integrity, ensuring reliable results from even the most challenging samples.
What are the key advantages of using Creative Biolabs' functional CD123 assays compared to standard expression analysis?
While expression analysis confirms target presence, our functional assays provide critical insights into the biological impact of your therapeutic agent. These assays help you understand how your drug interacts with CD123, its mechanism of action, and its potential efficacy, which is vital for preclinical development and lead optimization.
Related Services
Antibody-Drug Conjugate (ADC) Technology
Our comprehensive ADC development services span the entire process, from initial rational design based on target biology and payload mechanism of action, through meticulous synthesis and characterization.
Learn More →
Target Discovery & Validation
This involves employing cutting-edge technologies like mass spectrometry for comprehensive protein profiling, NGS for genomic and transcriptomic analysis, and sophisticated computational modeling to identify potential targets with high disease relevance.
Learn More →
How to Contact Us
Our comprehensive CD123 assay portfolio service provides the precision, depth, and reliability you need to accelerate your research and development. From initial target characterization to advanced functional analysis and minimal residual disease surveillance, we are committed to delivering actionable insights that drive your success.
Contact us for more information and to discuss your project.
Reference
-
El Achi, Hanadi, et al. "CD123 as a biomarker in hematolymphoid malignancies: principles of detection and targeted therapies." Cancers 12.11 (2020): 3087. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3390/cancers12113087
