Cell Line Development

Stable cell line shows a great capacity in many fields, especially in immunotherapy (including production of recombinant protein and monoclonal antibody), drug screening and gene function study. After years of hard work, Creative Biolabs can provide a stable cell line development service as per your requirement. Our cell line development service includes cell line construction, process development, cell banking and analysis, etc.

End-to-end process of cell line development.

Cell Line Construction

A stable cell line can reduce the production costs of biopharmaceuticals with high efficiency of productivity and desired critical quality. Our strategy is to identify highly productive clones. In our fed batch fermentation platform process, they are also selected to grow well in suspension culture, which can save time in the later stage of the production process. We offer a variety of approaches to cell line construction that can be chosen according to your priorities in terms of timelines, yield optimization and potential risks. Our team will perform cell line development service and provide you with reliable options to determine the best type to fit your project requirements. We are able to offer customized combinations according to your target recombinant proteins.

Processes of Cell Line Development:

We start with DNA or protein sequences provided by our clients, and eventually offer well-characterized, high-yielding, and stable monoclones.

Fig. 1 End-to-end process of cell line development.

Highlight Features

  • Advanced cell line development platform,
  • Open-access technology with flexible terms,
  • Robust cell line with high protein productivity with exceptional stability,
  • GMP cell line banking and supporting in-house cell line characterization,
  • Seamless integration with cGMP manufacturing and process development services,
  • Covering a comprehensive set of products including monoclonal antibodies, bispecific antibodies, antibody drug conjugates, enzymes, fusion proteins, and other recombinant proteins.

Equipment & Instrumentation

Our well established state-of-the-art molecular biology platform and cell biology platform render us the capability to perform a wide range of services required for successful cell line development.

  • High-throughput cell culture in 24-well plates, spin tubes, and shake flasks,
  • High-throughput expression and glucose / Lac assays,
  • High-throughput cell counting,
  • Automated high-throughput clone screening,
  • Automated clone picking.

Analysis

To validate if we get the desired cell line, we explore and develop the following analysis methods to screen and quantify our target gene and protein sequence, which companies and boosts the progress of our immunotherapy discovery.

  • Screening of clone productivity,
  • Target gene/protein expression,
  • Sequence analysis.

Comprehensive Supporting Services

  • Process development
  • Developability
  • Cell banking
  • Sequence analysis
  • Long-term productivity and genetic stability study
  • Analytical service

With extensive experience, Creative Biolabs offers a wide range of antibody and protein therapeutics. We are committed to your most trusted partner to meet all your needs for antibody and protein production using cell lines. For more information, please contact us and our team will get back to you as soon as possible.

For lab research only, cannot be used for any clinical use.

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