EGFR Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs provides precise patient stratification, enabling the identification of individuals most likely to respond to targeted therapies. Our advanced assays facilitate the early detection of acquired resistance mutations and minimal residual disease, allowing for timely therapeutic adjustments. Furthermore, Creative Biolabs offers robust tools for preclinical screening, mechanism-of-action studies, and clinical trial biomarker analysis, significantly de-risking the development of novel EGFR inhibitors and monoclonal antibodies.
EGFR as a Key Target in Oncology
EGFR (also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase (RTK) belonging to the ERBB family. The binding of EGFR ligands to the extracellular domain of EGFR will lead to receptor activation and stimulate downstream signaling pathways, which are crucial for cell proliferation and growth. Aberrant activation of EGFR will ultimately lead to uncontrolled proliferation, which is also a hallmark of cancer cells.
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Fig.1 EGFR-mediated signaling pathways and related therapy.1
What We Can Offer
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In Vitro Assays
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In Vivo Assays
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EGFR Target Validation and Related Analysis
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Binding Affinity Test
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Epitope Mapping
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Functional Assay
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Model Construction: Develop and validate appropriate animal models, including Patient-Derived Xenograft (PDX) models.
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PK/PD Study: Analyze your compound's pharmacokinetics and pharmacodynamics to understand its efficacy and safety.
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Workflow of EGFR Assay Portfolio Service
Highlights
One-Stop Comprehensive Service
From EGFR target validation, binding affinity testing, epitope mapping, and functional assays to comprehensive in vivo model construction and crucial PK/PD studies, we provide integrated solutions that streamline your project from initial discovery through preclinical development.
Unrivaled Expertise & Advanced Platforms
We continuously invest in advanced technologies like next-generation sequencing (NGS) and ultra-sensitive digital droplet PCR to ensure superior accuracy and sensitivity in all our assays.
Unwavering Commitment to Quality
We implement rigorous quality control (QC) at every stage, from sample processing to data analysis, ensuring the reliability and trustworthiness of our results, which provides you with confidence in the actionable insights derived, supporting critical publications and regulatory submissions.
Flexible & Customized Solutions
Whether you require high-throughput screening for large compound libraries, rapid targeted single-gene analysis, or support across the entire drug discovery pipeline, our solutions are perfectly scalable.
Customer Reviews
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Invaluable Data Interpretation
The comprehensive NGS profiling from Creative Biolabs' service facilitated our understanding of complex resistance patterns in patient samples. Their detailed reports and expert interpretation saved us countless hours, allowing us to focus on downstream therapeutic development. - Prof. Js Wg.
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Accelerated Drug Development
Creative Biolabs' service provided invaluable insights into the functional activity of our novel compounds through their ELISA-based phosphorylation assays. Their rapid turnaround times meant we could iterate on our drug candidates much faster. - Dr. Sh Kr.
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FAQs
What types of samples can I submit for EGFR analysis?
We accept a wide range of sample types, including FFPE tissue blocks, fresh-frozen tissue, liquid biopsy samples (plasma, serum, CSF), isolated DNA/RNA, and cell lines. Each sample type offers unique advantages for specific analytical needs. For instance, FFPE tissues are invaluable for retrospective studies and spatial analysis, while liquid biopsies provide a non-invasive means for real-time monitoring of disease progression and treatment response.
Can your service be customized for rare or novel EGFR mutations?
Absolutely. Our NGS platforms are highly adaptable for comprehensive profiling, capable of detecting known and novel EGFR alterations across multiple exons with high sensitivity. Furthermore, our dedicated custom assay development team excels at designing and validating bespoke assays.
How does Creative Biolabs ensure the quality and accuracy of EGFR assays?
We adhere to stringent quality control measures at every stage of our workflow, from initial sample processing and nucleic acid extraction to assay execution and final data analysis. Our assays are validated for sensitivity, specificity, and reproducibility using certified reference materials and rigorous internal controls.
Related Services
Oncology Biomarker Discovery
Our expertise extends to comprehensive profiling using advanced genomic, proteomic, and metabolomic approaches, enabling the discovery of new targets and pathways that can inform drug development and personalized treatment strategies.
Learn More →
Preclinical Efficacy Studies
Conduct rigorous in vitro and in vivo models to assess the efficacy and mechanism of action of your investigational compounds targeting EGFR or other oncogenic pathways.
Learn More →
How to Contact Us
Ready to advance your precision oncology initiatives? Our EGFR assay portfolio service helps you accelerate drug discovery, optimize patient outcomes, and streamline clinical trial processes through a comprehensive suite of advanced analytical technologies and expert interpretation. Contact us for more information and to discuss your project.
Reference
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Ali, Remah, and Michael K. Wendt. "The paradoxical functions of EGFR during breast cancer progression." Signal transduction and targeted therapy 2.1 (2017): 1-7. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1038/sigtrans.2016.42
For Research Use Only | Not For Clinical Use
