Fig.1 Macrophage-mediated activation of
innate immunity by agonistic LPS.
(Alexander, 2001)
lipopolysaccharides (LPS) play an important role in the growth or survival of bacteria, the interaction between host and parasite, the immunity reaction, and the toxic pathophysical reaction. Thus, the analysis of LPS is significant in medicine and many other fields. Creative Biolabs provides LPS analysis service to assist in the study of bacterial pathogenesis.
Bacterial LPS, also known as endotoxin, are the major outer surface membrane components present in almost all Gram-negative bacteria. LPS acts as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. It consists of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A which is the primary immunostimulatory center of LPS. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but the higher doses can also lead to pathological reactions such as the induction of septic shock. Therefore, the analysis and characterization of LPS has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes but is also conducive to the development of related pharmacology and immunostimulatory for the prevention and therapy of infectious and malignant diseases.
Our LPS analysis service includes the following methods to adapt to your multiple needs:
✔ Application:
On demand SDS-PAGE profiles of your LPS
✔ Advantages:
The best gel and solvents and various LPS standard were selected
A rapid way of getting access to LPS profiles on gel
✔ Application:
LPS characterization
Antigen screening and selection
Antigen characterization and validation
✔ Advantages:
Various LPS standards were selected, various culture strains were compared
Various sample were analysis and characterization accurately
✔ Application:
Determine the content of activity of LPS in human serum, plasma, tissue and related liquid.
✔ Advantages:
Simple and fast
Stable repeatability and reliability
Highly effective, sensitive and specific antibody
With a team of professional and well-equipped experts, Creative Biolabs is dedicated to working with researchers around the world to meet customer requirements and ensure the quality of our LPS analysis service. For more detailed information, please feel free to contact us or directly sent us an inquiry.
Reference
For Research Use Only | Not For Clinical Use
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