PSMA Assay Portfolio Service

Biology and Function of PSMA

PSMA is a transmembrane glycoprotein overexpressed on prostate cancer cells and the neovasculature of many other solid tumors. Its expression levels are correlated with disease progression, making it a highly attractive target for precision oncology. PSMA can enzymatically hydrolyze glutamated folates, producing glutamate and folates that can enter the cell through proton-coupled folate transporter (PCFT), folate receptor (FR), or reduced folate carrier (RFC).

What We Can Offer

Functional and Cellular Assays	Protein and Molecular Characterization
Cell Proliferation and Cytotoxicity Assays Apoptosis Evaluation via TUNEL Assay Cell Adhesion Studies	Immunoprecipitation Immunofluorescence and Immunohistochemistry Western Blot Analyses

Highlights

Decades of Specialized Expertise

Our deep knowledge base allows us to anticipate and troubleshoot potential challenges before they arise, optimize every step of your experimental design, and provide strategic guidance that helps you navigate the complexities of PSMA-targeted therapeutic development.

Rigorous Quality and Standardization

We guarantee that your results are not only consistent and reproducible but also highly reliable, eliminating the inherent variability and uncertainty that can often plague in-house assay development. This gives you the data confidence required for your most critical milestones.

Holistic Data and Insights

Our comprehensive portfolio allows you to evaluate your molecules from multiple angles, seamlessly connecting biochemical data with functional cellular effects. This integrated approach provides you with a deeper, more robust understanding of your compound's mechanism.

Dedicated Partnership and Support

We are your dedicated partner in discovery. Our team is committed to a collaborative approach, providing expert consultation and interpretation from the initial discussion to the final report, ensuring you have the support you need throughout your entire research program.

Experience the Creative Biolabs advantage - Get a quote today.

Customer Reviews

Accelerated Drug Screening
Using Creative Biolabs' PSMA assay portfolio in our research has significantly improved the efficiency. Their HTS platform allowed us to move from a library of thousands of potential candidates to a handful of potent leads in a fraction of the time, shortening our discovery phase. - M*ke.

Insight into Cellular Function
The cellular assays offered by Creative Biolabs gave us a much-needed understanding of our compound's mechanism of action in a live cellular context. The apoptosis evaluation via TUNEL assay was particularly insightful and provided critical data. - P*ul.

FAQs

How do you ensure the reproducibility and quality of your data?

All of our assays are developed and validated under strict SOPs, which ensure high levels of consistency and reliability. We implement a tiered QC system that includes plate-to-plate and day-to-day validation, ensuring the robustness of our data. We also provide full transparency with raw data, detailed reports, and a comprehensive analysis of the results, so you have complete confidence in the integrity of our findings.

What is the primary advantage of your portfolio compared to developing my in-house assays?

Our service provides a significant, cost-effective, and time-efficient solution. You gain immediate access to our fully validated, high-throughput platform and our extensive expertise, eliminating the need for a substantial investment in equipment, reagents, and specialized personnel. This allows you to accelerate your research timeline and de-risk your project.

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Target Discovery and Validation

Our advanced discovery platforms leverage cutting-edge bioinformatics and high-throughput screening technologies to help you identify and validate other novel targets for your oncology program.

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Cell Line Development Service

This includes the generation of cell lines with inducible or knockdown PSMA expression, as well as reporter cell lines designed for specific functional assays.