STAT3 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs delivers precise data on key STAT3 activation steps, including phosphorylation, dimerization, nuclear translocation, and transcriptional activity. Our service enables you to identify potent and selective STAT3 inhibitors, elucidate their mechanism of action, and guide your lead optimization efforts with confidence. Creative Biolabs also offers insights into how your compounds might influence the immunosuppressive tumor microenvironment fostered by STAT3, paving the way for novel immunotherapies.
Tumor Target STAT3
STAT3 is a member of the STAT family, typically activated by upstream cytokine receptors and growth factor kinases. Meanwhile, non-receptor tyrosine kinases such as ABL and SRC can also cause constitutive activation of STAT3. Phosphorylated STAT3 forms a dimer and simultaneously localizes to the nucleus, leading to the transcription of target genes, including immunosuppression, angiogenesis, metastasis, and proliferation.
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Fig.1 The domain structure and signaling pathway of STAT3.1
What We Can Offer
Integrated Discovery and Characterization
We provide end-to-end support, from high-throughput primary and secondary screening to identify promising drug candidates, to a wide range of in vitro cell biology assays that provide functional insights into your compounds' biological impact.
Translational Support for In Vivo Studies
We generate critical in vitro data that seamlessly informs and guides your in vivo research. Our services help you identify key biomarkers, select optimal doses, and provide mechanistic validation to streamline the transition to animal models and interpret observed anti-tumor effects.
Advanced Oncology and Safety Profiling
Our in-depth oncology analysis includes pathway mapping and gene expression profiling to provide a holistic view of your compound's effects. We also offer early-stage safety and toxicology support to de-risk candidates, helping you guide lead optimization towards safer and more effective therapies.
Workflow of STAT3 Assay Portfolio Service
Highlights
Comprehensive & Targeted Solutions
We provide comprehensive and accurate analysis for STAT3-targeted drug screening, in vitro cell biology, and crucial support for both in vivo pharmacodynamic and oncology efficacy models.
Unparalleled Expertise & Advanced Technology
Our state-of-the-art facilities and advanced assay technologies ensure that you benefit from the most sophisticated tools and methodologies available for precise oncology analysis and safety assessment.
Mastery of STAT3 Complexity
We possess a deep understanding of the intricate STAT3 signaling pathway, including its role in fostering an immunosuppressive tumor microenvironment and its various post-translational modifications.
Strategic Partnership for Therapeutic Impact
We provide the critical data and expert guidance needed to navigate complex drug discovery landscapes and unlock new therapeutic avenues, facilitating your scientific research and shortening project timelines.
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Customer Reviews
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Precise MoA Elucidation
Creative Biolabs' detailed mechanistic insights were invaluable, combining phosphorylation, DNA binding, and nuclear translocation analyses. This enabled a precise understanding of our compound's mechanism of action, which was crucial for guiding subsequent SAR studies. - S*ra L.
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Reliable Data for Immunotherapy
Creative Biolabs' service provided consistently reliable data on STAT3's role in immune evasion. This enabled us to confidently design effective combination therapies with immune checkpoint inhibitors. - M*ke P.
FAQs
What types of compounds can be screened using your STAT3 assays?
Our assays include small molecules, which are often the initial focus of high-throughput screens due to their diverse chemical space; peptides, offering high specificity and often mimicking protein-protein interactions; and decoy oligonucleotides, designed to directly interfere with STAT3 DNA binding.
How do your STAT3 assays compare to in-house methods?
Our service leverages state-of-the-art platforms equipped with advanced automation and detection technologies, such as high-content imaging systems and sensitive luminescence/fluorescence readers. This allows for significantly higher reproducibility, enhanced sensitivity to detect subtle compound effects, and superior throughput compared to many conventional in-house setups.
What precautions should we consider when preparing our compounds for your service?
To ensure optimal assay performance and the most reliable results, we strongly recommend providing compounds with confirmed purity and solubility. Impurities or poor solubility can interfere with assay readouts or lead to inaccurate concentration measurements.
Related Services
Cell Line Development
We can engineer stable cell lines with constitutive STAT3 activation, inducible STAT3 expression, specific STAT3 mutations, or integrated STAT3-responsive reporter genes.
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Biomarker Discovery
This includes the discovery of gene expression signatures, protein phosphorylation patterns, or circulating factors that correlate with STAT3 activity and therapeutic response.
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How to Contact Us
Ready to advance your precision oncology initiatives? Partner with Creative Biolabs and leverage our comprehensive STAT3 assay portfolio service to accelerate your drug discovery efforts. Our deep understanding of STAT3 biology, coupled with our rigorous assay development and validation processes, ensures that you receive the most accurate and actionable insights.
Contact us for more information and to discuss your project.
Reference
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Zou, Sailan, et al. "Targeting STAT3 in cancer immunotherapy." Molecular cancer 19.1 (2020): 145. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1186/s12943-020-01258-7
For Research Use Only | Not For Clinical Use
