Viability and biodistribution studies provide preliminary data on early tolerance dose, cell survival and CAR/TCR cells kinetic activity of cellualr or gene therapy products. Experimental studies, including elucidating in vivo routes of action, dosing regimens, dose response and utility, and duration of action, provide strong conceptual evidence in selected animal models.
As a leading provider of biotechnology services, Creative Biolabs provides comprehensive pre-clinical viability and biodistribution studies analysis for cell and gene therapy. All tests are performed by experienced technicians using state-of-the-art technology on the most appropriate animal models.
Cell viability can be measured based on different parameters, such as the redox potential of the cell population, the integrity of the cell membrane, or the activity of cellular enzymes. Each assay provides a different snapshot of cell health and can reflect cell viability individually or together, revealing cytotoxicity or drug efficacy. Creative Biolabs offers a variety of options for cell viability assays:
Creative Biolabs offers GLP compliant assessments for the survival of cell or gene therapy products in animal models, tracking their integration in non-target tissues, and the ability to differentiate and migrate at target sites.
For CAR living cells, we can label or stain them in a variety of methods. For example, in cell culture, they can be easily labeled with intracellular dyes such as 5-carboxyfluorescein diacetate succinimidyl ester, 5-bromo-2'-deoxyuridine (BrdU), or green fluorescent protein GFP, followed by in vivo fluorescence imaging.
For more details, please feel free to contact us for project quotations and more detailed information.
For Research Use Only | Not For Clinical Use
Download our brochure