Dilated cardiomyopathy (DCM) is one of the most common cardiomyopathy subtypes with clinically characteristic by ventricular dilation and impaired contraction. This disease cell model belongs to DCM, a mutation (R225X) occur in the LMNA/C gene. Generating pluripotent stem cells from dermal fibroblasts, then differentiate into cardiac myocytes. This disease cell model provides a platform to explore disease mechanisms in human genetic cardiac disorders.
Specifications | |
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Organ System | Cardiovascular System |
Disease | DCM |
Target Gene | LMNA/C |
Gene Function | Lamin A and C originate through alternative splicing of the same gene and only differ in the carboxy-terminal domain. |
Mutation | R225X |
Phenotype | Increased apoptosis and senescence, altered nuclear architecture |
Source | Dermal fibroblasts |
Cellular Assays | Whole-cell patch clamp techniques, immuofluorescence staining |
Target Gene | |
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Gene ID | 4000 |
For Research Use Only. Not For Clinical Use.