There is no doubt that the emergence of immunotherapy has redefined the field of cancer treatment as breakthrough progress. Most immunotherapies now focus on the adaptive immune response, that is, on TRead More…
A study at the Stanford University School of Medicine showed that altered immune cells can eliminate a fatal pediatric brain tumor in a mouse model, which was published in the April 16Read More…
Huge progress has been made in the CAR-T field recently. Professor Koji Tamada from Yamaguchi University, Department of Immunology, has successfully developed a new generation of CAR-T. Meanwhile, in a variety of solidRead More…
Recently, CAR-T therapy has achieved continuous breakthrough results. First, scientists from the United States and Italy found a better target for CAR-T against a fatal brain tumor. Then, a research team fromRead More…
On February 1, NEJM, the top medical journal, published the results of a pivotal multi-center critical phase 2 trial in support of the “first CAR-T therapy Tisagenlecleucel listed”. The overall survival of patientsRead More…
Chimeric antigen receptor, or CAR, T cells have considerably improved cancer treatment outcomes for certain malignancies. CAR T cells are produced when T cells isolated from the patient are modified to targetRead More…
As we all know, CD19 is the most frequently used target marker for CAR-T cell therapy clinical trials. But not much people knows about the second frequently used target biomarker is mesothelin. What’s more,Read More…
As the data from clinicaltrials.gov shows, CD19 antigen is the most frequently used biomarker in CAR-T cell therapy clinical trials for hematological malignancy such as leukemia and lymphoma. According to our statistics report, overRead More…
T cell receptors (TCRs) provide a recognition signal for T cells complemented by a co-stimulatory signal that can provide an on/off signal to regulate the activation of T cells. Since Medawar andRead More…
As we know, a typical design of 2rd generation Chimeric antigen receptor contains 3 functional units: a recognition domain, a transmembrane spacer domain and an intracellular signal transduction domain. Antigen recognition domainRead More…