In the current landscape of drug discovery, membrane protein targets remain the undisputed crown jewels. Whether it is G protein-coupled receptors (GPCRs), ion channels, or transporters, these proteins are inextricably linked toRead More…
As antibody drugs continue to target complex membrane proteins and immunomodulatory targets, traditional antibody discovery methods based on recombinant proteins are facing challenges such as conformational distortion and loss of post-translational modifications.Read More…
Antibodies are a class of proteins that are important to the body’s immune system. Immunoglobulin G (IgG) stores memories of past infections and marks dangerous microbes so they can be destroyed byRead More…
Neutralizing antibodies targeting HIV-1 Env have now been shown to protect against systemic infection. Recently, scientists from the University of Bochum in Germany and other institutions have discovered through research that HIVRead More…
Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibodies is also in full swing. AtRead More…
Human immunodeficiency virus 1 (HIV-1) is a retrovirus, and most HIV-1 infections occur on the mucosal surface of the human reproductive tract. After HIV-1 enters the nucleus of the host cell, itRead More…
Therapeutic Antibody Drugs Since the first clinical application approval in 1986, more than 100 therapeutic antibody drugs have entered clinical application successively, and new antibody drugs are in the process of developmentRead More…
Introduction to antibody structure and function An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab region is a mixed light andRead More…
G protein-coupled receptor (GPCR) is a very important receptor protein on the cell surface. In the human genome, GPCR-encoding genes account for more than 2% and contain more than 800 members, makingRead More…
Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library technology were applied earlier, and singleRead More…