2 CD47-related Signaling Pathways The extracellular ligands interacting with CD47 are TSP1, SIRP α, and CD47 itself. Among them, little is known about the signal transduction involved in the homotypic interaction ofRead More…
Cluster of differentiation 47 (CD47) is a widely expressed glycoprotein on the cell surface, which can interact with a variety of intracellular and extracellular proteins such as thrombospondin-1 (TSP-1) and signal regulatoryRead More…
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, theRead More…
In a new study, an international team led by the University of Bonn identified and further developed the novel single-domain antibodies (sdAbs) against SARS-CoV-2. The researchers also combined these single-domain antibodies intoRead More…
In a recent study, the scientists at UT Southwestern have developed a new method to study the molecular characteristics of T cells. The method, published on Nature Methods, makes it easier forRead More…
Recently, the phase 3 clinical trial results of T cell receptor (TCR) therapy, tebentafusp, have been released. The results showed that it reached the primary endpoint in the treatment of metastatic uvealRead More…
A new study published on eLife shows when T cells in the immune system find and identify targets, they release chemicals to attract more T cells, and then gather to help suppressRead More…
The 2020 Nobel Prize in Physiology or Medicine is awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus”. Thanks to their discovery,Read More…
According to the latest report from the Science, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients who died of COVID-19 and found thatRead More…
CD38 protein, which was discovered in 1980, is a type II transmembrane glycoprotein with a size of 46 kDa. The ligand of CD38 is CD31, also known as PECAM-1, which is aRead More…