Introduction to antibody structure and function An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab region is a mixed light andRead More…
G protein-coupled receptor (GPCR) is a very important receptor protein on the cell surface. In the human genome, GPCR-encoding genes account for more than 2% and contain more than 800 members, makingRead More…
Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library technology were applied earlier, and singleRead More…
Basic Structure of ADCs Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytotoxic small molecule payloads, and linkers. The basic structureRead More…
Following the accomplishment of the PEGS Summit, 2022 BIO International Convention, and 13th Annual World ADC, this month’s Creative Biolabs event was held this week at the DoubleTree Boston North Shore ConventionRead More…
The study findings, titled “Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination,” were published in Nature by a team of researchers from the University of California, San Francisco, and the affiliated GladstoneRead More…
Multiple myeloma is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, in a recent study published in Science Translational Medicine entitled “Selective targeting of multiple myeloma cellsRead More…
Vascular dysfunction contributes to the pro-oncogenic tumor microenvironment and impedes the delivery of therapeutic drugs, so normalizing tumor blood vessels may become a potential path. Scientists have developed a new type ofRead More…
3 Relationship Between CD47-related Signaling Pathways and Diseases 3.1 Cancer CD47 is highly expressed on the surface of many kinds of tumor cells, which, as a signal molecule of “don’t eat me”,Read More…
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, theRead More…