The development concept of single domain antibody-drug conjugates (sdAb-drug conjugates) is similar to that of antibody-drug conjugates (ADCs). That is, the antibody in the ADC is replaced with a single domain antibodyRead More…
As a type of antibody with good application prospects, single domain antibodies have advantages in the diagnosis and treatment of many diseases. However, its short half-life in plasma limits its application inRead More…
Single domain antibodies have been widely used as antigen-binding domains in CAR-T due to their small size, excellent stability, high affinity, and strong manufacturing feasibility. Single domain antibody-based CAR constructs have shownRead More…
The single-domain antibody has similar antigen binding characteristics to the traditional antibody. But, because single-domain antibodies use a single Ig variable domain for antigen recognition, they can access epitopes that cannot beRead More…
Cancer Monoclonal antibodies against cancer therapy are now on the market to treat cancer by recognizing cancer-related antigens. However, it is difficult for monoclonal antibodies with large molecular size to penetrate theRead More…