The human gut microbiota has been considered the most important micro-ecosystem living in symbiosis with the body and is associated with many diseases. Based on a cutting-edge Gut Microbiota-Based Diagnostics Platform, Creative Biolabs provides gut microbiota analysis and characterization services, which help create a better-understand role of gut microbes in human health and disease.
The gut microbiota is described as a complex and abundant ecosystem, composed of trillions of microorganisms. In the clinical context, the human gut microbiome has been the subject of intense investigation, which has revealed a sophisticated interplay between the microbiome and the host immune system and metabolism. Analyses of gut microbiotas have been used to assess host health and foster disease prevention and treatment. Creative Biolabs has served clients from around the world for their gut microbiota projects. We provide a complete solution for gut microbiota analysis and characterization.
In the past, microbiology was entirely culture-dependent throughout a century. This approach has limited the range of detectable organisms to those that would proliferate in the setting of actual laboratory culture conditions. Great progress was made by analyzing the DNA extracted directly from a sample derived from the site of interest-based on culture-independent methods. The earliest DNA-based methods probed extracted DNA of a microbial community for genes of interest by using fluorescent in situ hybridization (FISH). Alternatively, specific genes are amplified by polymerase chain reaction (PCR), cloned in E. coli and subsequently sequenced. Recently, metagenomics, metatranscriptomics, metaproteomic and metabolomics have provided us with deep knowledge related to important interactions such as host-microbiota and microbe-microbe interactions under various perturbations inside the gut.
Fig.1 Various methods for identifying and studying the gut microbiota and microbiome. (Philips, 2020)
Nowadays the advent of innovative high-throughput sequencing allows obtaining high-quality microbiome profiling. However, the pure culture of intestinal microbiota remains essential to define the roles of specific bacteria in the gut. PCR-based tests are still considered the “golden standard” for many clinical applications. At Creative Biolabs, we provide culture- and quantitative PCR (qPCR) based-analysis services.
Creative Biolabs has established microbiology laboratories to culture and analyze gut microbiota.
qPCR provides a simple and accessible method for quantitative microbiota profiling.
Gut microbiota analyses require expert input to get high-quality and reproducible data. We help with research applications that require professional microbiota analysis delivered by experts in the field. All of Creative Biolabs' gut microbiota analysis services include comprehensive bioinformatics and statistical analyses as well as group comparisons, presented in a user-friendly and interactive report. If you are interested in our service, please contact us for further information.
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For Research Use Only | Not For Clinical Use
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