Correct folding proteins play critical roles in maintaining cell and body health. While some proteins will aggregation in a misfolded state resulting in diseases influenced by mutations, environments, aging or other unclear reasons. For example, several neurodegenerative diseases, cancers, and type 2 diabetes mellitus (T2DM) are caused by these misfolding or misregulated proteins. However, these potential targets are undruggable by traditional small molecular inhibitors. PROTAC®s emerges with great potential to eliminate these undruggable protein targets with proper binding activity, let alone for a druggable target with better safety. Multiple targets have been targeted, including but not limited to human epidermal growth factor receptor 3 (HER3), the estrogen receptor alpha receptor, androgen receptor (AR), methionine aminopeptidase-2 (MetAP-2), BRD family members. Here Creative Biolabs offers several ready-to-use target proteins to our worldwide clients and we have services to produce required target proteins based-on our cell-based and cell-free expression system.
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