Ligands

PROTAC^®s are an emerging technique to target the “undruggable” proteins, such as transcription factors and non-enzymatic proteins. The major parts of PROTAC^®s are two ligands, one binds to the protein target of interest, and the other binds an E3 ligase. Although usually either Cereblon or Von Hippel-Lindau is applied as the E3 protein, in principle, our human genome encodes more than 600 E3 ligases. The minimal number of the specific ligands to these E3 proteins should be equal to the number of E3 ligases. Meanwhile, various ligands can be used to specifically bind to corresponding target proteins and recruit these proteins to the E3 ligase. Creative Biolabs provides E3 ligase ligands, ligand-linker conjugates, target ligands, and intact PROTAC^® molecules to makes it possible to develop a vast array of PROTAC^®s for drug discovery.

BRD9-Binding Moiety 1 Hydrochloride(CAT#: PRLG-001)

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Type: Target ligand

Size: 5 mg

Physical State: Powder

VH 032 Amine Hydrochloride(CAT#: PRLG-002)

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Type: E3 ligase ligand

Size: 5 mg

Physical State: Lyophilized white powder

Thalidomide Linker 1(CAT#: PRLG-003)

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Type: Ligand-linker conjugate

Size: 10 mg

Physical State: Lyophilized white powder

dBET1(CAT#: PRLG-004)

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Type: PROTAC^® molecule

Size: 5 mg

Physical State: Lyophilized white powder