PROTAC®s are small molecule-based novel technology to target proteins for degradation at the post-translational level. There were studies suggest that the length of the linker is critical for the activity of PROTAC®s. Therefore the distance between the E3 ubiquitin ligase and the target protein is important. Typically, the length varies from 12-carbon to over 20-carbon. In addition, scientists revealed the orientation of the E3 ubiquitin ligase and the target protein also matters. Creative Biolabs offers a variety of linker products including alkyl-chains, PEGs, alkyl/ethers, etc to customers to optimize, helping to obtain the most effective one in ubiquitination of the target protein and its ultimate degradation.
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