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PROTACs are small molecule-based novel technology to target proteins for degradation at the post-translational level. There were studies suggest that the length of the linker is critical for the activity of PROTACs. Therefore the distance between the E3 ubiquitin ligase and the target protein is important. Typically, the length varies from 12-carbon to over 20-carbon. In addition, scientists revealed the orientation of the E3 ubiquitin ligase and the target protein also matters. Creative Biolabs offers a variety of linker products including alkyl-chains, PEGs, alkyl/ethers, etc to customers to optimize, helping to obtain the most effective one in ubiquitination of the target protein and its ultimate degradation.