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In Vivo ADME

Except for in vivo toxicity tests, Creative Biolabs also provides in vivo ADME studies to evaluate the ADME profiles of PROTAC®s applied in animal models. With more than 10 years of extensive experience in drug discovery and development services, we are committed to being your best partner in PROTAC® research area.

Background

ADME is designed to investigate the pharmacokinetics and pharmacology for absorption, distribution, metabolism, and excretion of potential small molecule drugs which is a critical part of the comprehensive safety evaluation and disposition of a pharmaceutical compound within an organism. The results of ADME can provide accurate assessment of pharmacokinetics and metabolism of drug exposure to the animals which contributes to the ultimate success or failure of the tested compound. Hence, ADME can influence the behavior, utility and pharmacological activity of the tested compound that is determinant for its potential capability as a drug.

Schematic diagram of ADME principle Fig.1 Schematic diagram of ADME principle (from EUPATI)

Introduction of In Vivo ADME

In vivo ADME can provide guidance in lead candidate selection, lead optimization, preclinical testing, and clinical programs. Creative Biolabs offers a variety of in vivo ADME studies in different animal models using radio-labeled materials either you provide or we synthesize by different administration routes. The regular isotopes we routinely work with include 3H, 14C, 32P, 35S, 33S, 90Y, and 125I, other isotopes are also available as per your specific request.

  • Animal models
  • Different disease models developed in different species can be realized in Creative Biolabs.

  • Routes of administration
  • We provide various routes, including oral, intravenous, dermal, intraperitoneal, inhalation, intrathecal and infusion or other delivery methods for your flexible choice to best fit your project.

  • Which ADME studies available?

    With advanced in vivo assay platform and experienced analytical technique, we can provide our clients with the following studies to evaluate ADME properties. If you are interested in only one aspect of ADME properties, you are also welcomed to contact us for a specific individual module to solve your specific question.

    • Metabolite isolation, profiling, and characterization
    • Bioavailability evaluations
    • Bioequivalence studies
    • Formulation screening and optimization
    • Dosing frequency evaluation
    • Routes of administration
    • Interspecies comparisons
    • Tissue distribution studies
    • Potential sites of toxicity
    • Mass balance studies
    • Excretion evaluation studies
  • Other supporting services
  • Creative Biolabs is always here to provide quality solutions to your pharmacokinetics or drug metabolism issues. In addition, our scientists can provide consultancy services with respect to the data interpretation, data analysis, issue resolution, strategic planning and due diligence for ADME studies.

Highlight Features of Our Services

  • Complete ADME service package
  • Various administration routes and animal models and studies to best fit your needs
  • High efficient studies and accurate data processing platform
  • Experienced scientists and skillful technicians

With rapid development of Creative Biolabs, we have established a perfect one-stop PROTAC® service platform for numerous worldwide clients from initial PROTAC® molecule discovery, in vitro PROTAC® evaluation to in vivo animal tests. We guarantee high assay efficiency and quality data which has already been recognized by our regular and new clients. We will always be dedicated to supporting PROTAC® research and exploring new services, and contributing to a healthier world for us. If you are interested in any individual study or a package service, please contact us for more details.

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