Creative Biolabs has established a one-stop platform for the development of genetically modified tumor cells. Based on the most cutting-edge technology and equipment, our scientists provide our clients with tailor-made services to construct IL-1-modified cancer cells. Our scientists with extensive experience and expertise will save your precious time and effort in your research.
Interleukin-1 (IL-1) cytokines are key proinflammatory cytokines that have been implicated with differing pro- and antitumorigenic properties. It is a general name for two distinct proteins, IL-1α and IL-1β. IL-1β is solely active in its secreted form, whereas IL-1α is mainly active in cell-associated forms (intracellular precursor and membrane-bound IL-1alpha) and only rarely as a secreted cytokine. These two cytokines, so often grouped together, have been shown to have different physiological and biological effects in different cancer types.
IL-1 support anti-tumor immunity by:
Fig.1 Overview of pro- and antineoplastic functions of IL-1β. (Gottschlich, et al., 2021)
Tumor cells are generally thought to be poorly immunogenic. A variety of cytokines have been used to generate immunogenic tumor cells by gene modification. Immunization with tumors expressing certain cytokines has demonstrated their ability to promote the generation of tumor-specific cytotoxic T lymphocytes by various mechanisms. In many situations, preimmunization with such gene-modified tumor cells elicited long-lasting protective immunity.
Cancer gene therapy approaches utilizing cells modified with IL-1 genes seem to represent a novel promising approach. Creative Biolabs provides cancer cell modification services to improve antitumor immunity. Our services cover various types of tumors (including hematologic tumors and solid tumors) and a variety of cancer cell lines (including adherent cells and suspension cells). Our dedicated team has a proven record of delivering quality and timely results, with over a decade of experience in hundreds of cell lines. Our services and expertise can help clients meet appropriate requirements to advance their cancer immunotherapy.
Creative Biolabs runs complex projects, from genetic construction to cell characterization and bioassay development. Our experts design the most efficient scheme to save on costs and time for our customers. Based on specific project goals, our expert scientists will work with you to select the optimal technologies you can employ to construct IL-1 gene-modified cancer cells. If you have any special needs for our services, please don’t hesitate to contact us.
Reference
For Research Use Only | Not For Clinical Use
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