Aided by in-house scientists and advanced technology platforms, Creative Biolabs has a lot of experience in engineering ovarian cancer cells for self-destruction purposes to speed up clients' project development.
Ovarian cancer (OvCa) has a high mortality rate and is one of the common causes of cancer death in women. Many patients are diagnosed at a later stage (III and IV) as the absence of typical symptoms and effective early diagnostic strategy, while at that time, treatment options were pretty limited. In addition, the recurrence rate of patients who have recovered from ovarian cancer is also relatively high, generally 70-80% of patients relapse within 2-5 years. Therefore, there is a need to develop more strategies to support research in the treatment of ovarian cancer.
In recent years, many studies have found that ovarian cancer cells have complex interactions with immune cells in the nearby tumor microenvironment. The reciprocal signaling can alter immune responses and regulate disease progression.
At the same time, there is growing evidence that immune cells reprogram their environment by interacting with cytokines such as interleukin, chemokines, and growth factors. In ovarian cancer TME, cytokine signaling components consist of interleukins, chemokines, and STATs. Which play essential roles in immune cell recruitment in the TME and thus influence clinical outcomes in Ovarian cancer. Ovarian cancer cells and Immune cells interact by cytokines to form a comprehensive network at the tumor site, responsible for the overall progression of the tumor.
Fig.1 Regulation of the immune microenvironment in OvCa by cytokine signaling. (Luo, et al., 2021)
Creative Biolabs has developed a new strategy for the Ovarian Cancer immunotherapy study, providing related services whose purpose is to engineer ovarian cancer cells for self-destruction. It works like exploiting cancer cells to aid in their own destruction, which uses different means to transfect cytokines into cancer cells, and activates the immune system to destroy cancer cells.
-- Local immune activation, with a more robust and specific immune response to ovarian cancer cells.
-- Effective avoidance of common side effects of immune stimulants, such as immunotoxicity and even death.
-- Leading to long immunological memory.
Creative Biolabs is proud to offer integrative research development for global customers to meet your research needs. We have focused on the following ovarian cancer research topic for many years, including but not limited to:
For more detailed information, please feel free to contact us or directly sent us an inquiry.
References
For Research Use Only | Not For Clinical Use
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