As a reliable and trusted contract research organization, Creative Biolabs is dedicated to accelerating the development of cancer immunotherapies. With a state of art R&D facility and rich experience, we provide custom IL2-overexpressed cancer cell lines. Our scientists will work with you to design your cell line and perform quality control testing to help ensure that the cell line meets your requirement.
Interleukin-2 (IL2) is a pleiotropic cytokine and is initially called T-cell growth factor. IL2 plays a critical role in the activation of the immune system which could be a useful way to eradicate cancer. IL2 can induce T cell proliferation and differentiation and also cause its activation. It can promote CD8+T-cell and NK cell cytotoxicity activity, and modulate T-cell differentiation programs in response to antigens. IL2 is the first cytokine found to have therapeutic benefits for cancer. It was approved by FDA for the treatment of metastatic renal cell carcinoma and metastatic melanoma, but it is associated with significant toxicity and even life-threatening syndromes. Some IL2-associated therapies offer many possibilities and promising results for cancer treatment.
Fig.1 IL‑2 homeostasis in steady-state conditions and during an immune response. (Boyman & Sprent, 2012)
Tumor cells have been genetically modified to secrete the IL2 to induce potential immunostimulating and antineoplastic activities. A study showed IL2 gene-modified tumor had a significant inhibitory effect on tumor progression in the mouse bladder cancer model. Most importantly, long-term immunological memory was established in the "cured" mice. Some studies showed IL2 gene-transfected melanoma cell vaccine could achieve a potent antitumor effect via efficient activation of immune functions. In addition, a phase I/II study of the IL2/Lptn gene-modified neuroblastoma cell line as a vaccine is currently being evaluated in clinical trials.
Tumor cells are generally thought to be poorly immunogenic. A variety of cytokines have been used to generate immunogenic tumor cells by gene modification. Immunization with tumors expressing certain cytokines has demonstrated their ability to promote the generation of tumor-specific cytotoxic T lymphocytes by various mechanisms. In many situations, preimmunization with such gene-modified tumor cells elicited long-lasting protective immunity. From this, Creative Biolabs has developed a platform to engineer cancer cells with cytokines overexpression.
Tumor cells introduced and expressed IL2 genes represent a novel promising approach to enhance the antitumor immune response based mainly on T lymphocytes. Focused on the latest research, Creative Biolabs offers customized services to construct IL2-modified cancer cells. We provide a flexible suite of services and a deep bench of cell line development experts, so we can help you design a custom solution that fits your unique processes. From designing and synthesizing the requested vector to editing your cell line, we offer end-to-end cell line development.
We have established a mature platform and can provide you with engineering cancer cell line services according to your requirements. Our genetic methods include:
The following lists the available cancer cell lines:
Scientists at Creative Biolabs focus on cancer immunotherapy programs with the potential to bring great benefits to our clients. We have abundant expertise and advanced platforms that enable us to provide excellent services. If you are interested in our services, please don’t hesitate to contact us.
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For Research Use Only | Not For Clinical Use
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