Technologies for Tumor Profiling

Overview

Tumor profiling, a service also known as molecular profiling or biomarker testing, can provide specific information about the tumor's genetic composition and other biomarkers that constitute cancer's molecular signature. The purpose of tumor profiling exposes cancer-associated mutations, and identify targeted therapies. Utilizing various technologies can be important to creating a comprehensive understanding of cancer and to help expose cancer in challenging situations. At Creative Biolabs, we provide offer tumor profiling services that can identify the changes in DNA, RNA, and protein expression by several technologies. Some tumor profiling projects may use a combination of technologies to uncover complete cancer information.

Technologies for Tumor Profiling

Creative Biolabs utilizes complex workflows and proprietary technologies to provide in-depth tumor profiling. Our tumor profiling service can give more information about cancers and help explore relevant treatment options.

Next-generation Sequencing (NGS)-based Tumor Profiling

Next-generation sequencing (NGS) is an state-of-the-art technology to obtain a comprehensive view of the tumor's genomic profile. NGS technologies have allowed the detection of multiple DNA aberrations across multiple genes, including inversions/deletions, copy number variations, translocations, and gene fusions.

In Situ Hybridization (FISH)-based Tumor Profiling

In situ hybridization (ISH) is a molecular cytogenetics technique that harnesses labelled DNA or RNA sequences (probes) bind to specific nucleic acid sequences. The DNA/RNA targets of biology specimens can be visualized with two types of probes: fluorescent or chromogenic probes.

Polymerase Chain Reaction (PCR)-based Tumor Profiling

Polymerase chain reaction (PCR) is used to amplify and detect DNA and RNA sequences quickly and accurately. This technique can accurately, quickly, and economically detect a very small amount of tumor cells.

Immunohistochemistry (IHC)-based Tumor Profiling

Immunohistochemistry (IHC) is used to detect changes at the protein level in various tumor tissues. The assessment of tissue-specific genes through IHC substantially helps tumour identification and classification at each diagnostic step and creat personalized treatment plans.

Microarray-based Tumor Profiling

Microarray is a powerful technique used extensively for gene expression analysis. Microarray technology can simultaneously measure hundreds of gene expressions on a single chip, advancing cancer categorization. Microarray technology has the potential to supplement standard diagnostic procedures in oncology and permit a more individualized approach to patient management.

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Reference

Malone, E.R.; et al. Molecular profiling for precision cancer therapies. Genome medicine. 2020, 12(1): 1-9.

For Research Use Only | Not For Clinical Use