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Datasheets
| Specifications | |
|---|---|
| Product Description | dBET1 is a PROTAC® molecule comprising BET antagonist (+)-JQ1 conjugated to a cereblon E3 ubiquitin ligase ligand Phthalimide. It's a potent and selective BRD4 protein degrader. It can be used to deplete BET bromodomains in cancer cells and induce apoptosis to delay tumor growth. |
| Molecular Formula | C38H37ClN8O7S∙0.8H2O |
| Molecular Weight (Da) | 799.7 |
| Chemical Name | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity | 99.5% |
| Solubility | 40 mg/mL in DMSO |
| Size | 5 mg |
| Physical State | Lyophilized white powder |
| Storage | The power can be stored at -20 °C for 3 years. Store solutions at -80°C for up to 6 months or -20°C for up to 1 month. |
| Target Information | |
|---|---|
| Target Name | Bromodomain-containing protein 4 |
| Alternative Names | BRD4; CAP; HUNK1; HUNKI; MCAP |
| Introduction | BRD4 is a member of the BET (bromodomain and extra terminal domain) family. It is a chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Besides, it is often required for expression of Myc and other "tumor driving" oncogenes in hematologic cancers. |
| Gene ID | 23476 |
| UniProt ID | O60885 |
| Related Disease | NUT midline carcinoma |
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