Antiretroviral therapy can suppress HIV-1 replication, but the persistence of long-lived resting memory CD4+ T cells harboring latent pre-viral HIV-1 DNA prevents a cure. To date, clinical interventions based on Latency ReversalRead More…
Cancer cells often overexpress CD47, which induces the expression of the inhibitory receptor SIRPα on macrophages, thereby allowing them to evade phagocytosis and antitumor immunity. Pharmacological blockade of CD47 or SIRPα hasRead More…
Recently, a team of researchers from the Gustave Roussy Cancer Research Institute in France published a groundbreaking study in the journal “Cancer Discovery.” This study reveals, for the first time, that BCL-2Read More…
Recently, a research team from Emory University in the United States published their latest research findings in “Science Translational Medicine,” revealing for the first time that the immune-inhibitory receptor FcγRIIB on theRead More…
Immunotherapy is making significant advancements in oncology treatment. In 2021 alone, the FDA approved over a hundred monoclonal antibody drugs. Alongside monospecific antibodies, the development of multispecific antibodies is also in fullRead More…
Whole-genome doubling (WGD) is a recurring event in human cancer that promotes chromosomal instability and the acquisition of aneuploidy, but the three-dimensional (3D) assembly of chromatin in WGD cells and its contributionRead More…
Pfizer announced that the U.S. Food and Drug Administration (FDA) has granted priority review status to its biologics license application (BLA) for elranatamab, an anti-CD3/BCMA bispecific antibody (bsAb), with a decision onRead More…
A kind of chronic leukemia, myeloproliferative neoplasms (MPNs), can afflict patients for many years and some patients may require treatment to better manage this type of blood cancer, while others may experienceRead More…
Preventing cancer metastasis remains one of the main goals of current research, as most malignant cells can metastasize by exploiting abnormal leakage from blood vessels. In a recent study published in theRead More…
Neovascular age-related macular degeneration (nAMD ) and diabetic macular edema (DME) are retinal diseases that are the two leading causes of vision loss, affecting more than 40 million people worldwide. Roche recentlyRead More…