25Apr/18

Natrue: Altered Immune Cells Can Eliminate Childhood Brain Tumor in Mice

April 25, 2018Chimeric Antigen Receptor Research, NewsCAR-T, chimeric antigen receptor T cells, GD2, GD2 CAR-T cellsbiocart

A study at the Stanford University School of Medicine showed that altered immune cells can eliminate a fatal pediatric brain tumor in a mouse model, which was published in the April 16Read More…

10Apr/18

Nat Biotechnol: New Generation of CAR-T Can Easily Eliminate Solid Tumors

April 10, 2018Chimeric Antigen Receptor ResearchCAR Design & Construction Service, CAR-T, new generation CAR-T, ready to use productsbiocart

Huge progress has been made in the CAR-T field recently. Professor Koji Tamada from Yamaguchi University, Department of Immunology, has successfully developed a new generation of CAR-T. Meanwhile, in a variety of solidRead More…

14Mar/18

CAR-T Therapy Breakthrough Results Successively Published in Science and Nature

March 14, 2018Chimeric Antigen Receptor Research, NewsChimeric antigen receptor (CAR), CSPG4, Glioblastomabiocart

Recently, CAR-T therapy has achieved continuous breakthrough results. First, scientists from the United States and Italy found a better target for CAR-T against a fatal brain tumor. Then, a research team fromRead More…

27Feb/18

Oncolytic Virus Significantly Prolong Patients’ Survival in Brain Tumor Treatment

February 27, 2018Oncolytic Virus Therapy ResearchCAR-T, oncolytic adenovirus, Oncolytic Virusbiocart

The latest achievement published in Journal of Clinical Oncology showed that a common cold virus could attack deadly brain tumors to prolong patient survival after genetic modification. Researchers from the MD AndersonRead More…

09Feb/18

Carl June: The World’s First CAR-T Therapy Released the Latest Data

February 9, 2018Chimeric Antigen Receptor Research, Newsacute lymphoblastic leukemia (ALL), CAR-T, CAR-T therapy, Chimeric antigen receptor (CAR)biocart

On February 1, NEJM, the top medical journal, published the results of a pivotal multi-center critical phase 2 trial in support of the “first CAR-T therapy Tisagenlecleucel listed”. The overall survival of patientsRead More…

22Jan/18

CAR T Cells Manufacture Upgrades

January 22, 2018Chimeric Antigen Receptor Research, NewsCAR-T, Chimeric antigen receptorbiocart

Chimeric antigen receptor, or CAR, T cells have considerably improved cancer treatment outcomes for certain malignancies. CAR T cells are produced when T cells isolated from the patient are modified to targetRead More…

11Jan/18

What Is Mesothelin？

January 11, 2018Chimeric Antigen Receptor ResearchCAR-T, Mesothelin (MSLN), mesothelin CAR, mesothelin-targeted immunotherapiesbiocart

As we all know, CD19 is the most frequently used target marker for CAR-T cell therapy clinical trials. But not much people knows about the second frequently used target biomarker is mesothelin. What’s more,Read More…

10Jan/18

What Is CD19 Antigen?

January 10, 2018Chimeric Antigen Receptor Researchacute lymphoblastic leukemia (ALL), CAR-T, CD19 antigen, chimeric antigen receptors (CARs)biocart

As the data from clinicaltrials.gov shows, CD19 antigen is the most frequently used biomarker in CAR-T cell therapy clinical trials for hematological malignancy such as leukemia and lymphoma. According to our statistics report, overRead More…

09Jan/18

What the Next Generation T Cell Therapy Looks Like

January 9, 2018Chimeric Antigen Receptor ResearchCAR T cell design, CAR T technology, chimeric antigen receptors (CARs)biocart

T cell receptors (TCRs) provide a recognition signal for T cells complemented by a co-stimulatory signal that can provide an on/off signal to regulate the activation of T cells. Since Medawar andRead More…

06Jan/18

What Is the Important Role of the Transmembrane Spacer Domain in CAR Design?

January 6, 2018Chimeric Antigen Receptor Research2rd generation Chimeric antigen receptor, CAR-T, CD19-CARs, chimeric antigen receptor (CAR) Tbiocart

As we know, a typical design of 2rd generation Chimeric antigen receptor contains 3 functional units: a recognition domain, a transmembrane spacer domain and an intracellular signal transduction domain. Antigen recognition domainRead More…