Short Description
Determines total bile acids using 3-alpha-hydroxysteroid dehydrogenase.
Development Stage
Research-Grade Lipid Metabolism Assay Development
Description
The LipidFlux™ Bile Acid Assay Kit determines total bile acid levels, serving as a sensitive marker for cholestasis and hepatotoxicity in drug safety evaluations. This homogeneous assay supports the investigation of bile acid transporter function and liver metabolism in pre-clinical toxicology. It allows for the early detection of drug-induced liver injury (DILI) related to bile secretion defects.
Features
Homogeneous liquid reagents; Assessing hepatotoxicity and bile acid transporter function in drug safety panels.
Process Relevance
Hepatotoxicity Assessment (DILI)
Application Stage
Pre-clinical Safety
Applications
Assessing liver function and cholestasis markers in serum.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 530 nm / Em 585 nm)
Sample Type
Serum, plasma, urine, and other biological samples
Research Areas
Hepatology; Toxicology
Datasheet